个人简介：

石照应，2022年博士毕业于哈尔滨工业大学生物医学工程专业，2023年1月加入南方科技大学，历任高级研究学者、研究助理教授。主要研究方向为胚胎合子基因组激活机制研究、三维基因组高阶结构解析、基因编辑方法开发与优化，以热带爪蛙为模型进行疾病模型构建。已在Nature Genetics，PNAS，Cell Reports 等杂志发表多篇研究论文。

研究领域：

1. 调控合子基因组激活的母源因子鉴定；

2. 胚胎杂交致死的机制研究；

3. 全基因组调控元件的功能性鉴定；

4. 调控爪蛙再生能力的机制研究；

5. 基因编辑技术的开发与优化。

工作经历：

2023.11 - 至今，南方科技大学生命科学学院，研究助理教授；

2023.01 - 2023.10，南方科技大学生命科学学院，高级研究学者；

2014.09 - 2018.08，南方科技大学生物系，助理研究员；

2013.07 - 2014.08，中国科学院广州生物医药与健康研究院，研究实习员.

学习经历：

2018.9 - 2022.12，哈尔滨工业大学（南方科技大学联合培养项目），生物医学工程专业 博士学位，导师：陈永龙副教授；

2010.9 - 2013.07，贵州大学动物科学学院，基础兽医学专业 硕士学位；

2006.9 - 2010.07，贵州大学动物科学学院，动物医学专业 学士学位。

代表文章：

[1] Shi, Z. #, Liu, G. #, Jiang, H. #, Shi, S., Zhang, X., Deng, Y., Chen, Y. Activation of P53 pathway contributes to Xenopus hybrid inviability. Proc Natl Acad Sci USA., 2023, 120(21): e2303698120.

[2] Shi, Z. #, Xu, J. #, Niu, L. #, Shen, W. #, Yan, S. #, Tan, Y., Quan, X., Cheung, E., Huang, K., Chen, Y., Li, L., Hou, C. Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis. Cell Rep, 2023, 542(3): 112151.

[3] Shi, Z., Jiang, H., Liu, G., Shi, S., Zhang, X., Chen, Y. Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis. Cell Biosci, 2022, 12(1): 104.

[4] Ran, R. #, Li, L. #, Shi, Z. #, Liu, G., Jiang, H., Fang, L., Xu, T., Huang, J., Chen, W., Chen, Y. Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis. Mol Oncol, 2022.15(19): 2554-67.

[5] Niu, L. #, Shen, W. #, Shi, Z. #, Tan, Y., He, N., Wan, J., Sun, J., Zhang, Y., Huang, Y., Wang, W., Fang, C., Li, J., Zheng, P., Cheung, E., Chen, Y., Li, L., Hou, C. Three-dimensional folding dynamics of the Xenopus tropicalis genome. Nat Genet, 2021, 53(7): 1075-87.

[6] Shi, Z. #, Xin, H. #, Tian, D. #, Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., Chen, Y. Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system. Faseb J, 2019, 33(6): 6962-8.

[7] Hu, Z. #, Wang, L. #, Shi, Z., Jiang, J., Li, X., Chen, Y., Li, K., Luo, D. Customized one-step preparation of sgRNA transcription templates via overlapping PCR Using short primers and its application in vitro and in vivo gene editing. Cell Biosci, 2019, 9: 87.

[8] Sun, J., Wang, X., Shi, Y., Li, J., Li, C., Shi, Z., Chen, Y., Mao, B. EphA7 regulates claudin6 and pronephros development in Xenopus. Biochem Biophys Res Commun, 2018, 495(2): 1580-7.

[9] Hu, Z., Shi, Z., Guo, X., Jiang, B., Wang, G., Luo, D., Chen, Y., Zhu, Y. S. Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR-Cas9 and ssODN in human cancer cells. Cell Biosci, 2018, 8: 12.

[10] Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., Chen, Y. Targeted integration of genes in Xenopus tropicalis. Genesis, 2017, 55(1-2).

[11] Liu, Z., Cheng, T. T., Shi, Z., Liu, Z., Lei, Y., Wang, C., Shi, W., Chen, X., Qi, X., Cai, D., Feng, B., Deng, Y., Chen, Y., Zhao, H. Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos. Cell Biosci, 2016, 6: 22.

[12] Wang, F. #, Shi, Z. #, Cui, Y., Guo, X., Shi, Y. B., Chen, Y. Targeted gene disruption in Xenopus laevis using CRISPR/Cas9. Cell Biosci, 2015, 5: 15. (IF=9.584)

[13] Shi, Z. #, Wang, F. #, Cui, Y. #, Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., Chen, Y. Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis. Faseb J, 2015, 29(12): 4914-23.

[14] Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., Chen, Y. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development, 2014, 141(3): 707-14.