Yu Chung Tse, Ph.D., Associate Professor.He got his Ph.D. at 2007 in The Chinese University of Hong Kong, and then he worked as Postdoctoral fellow in The University of Chicago for 5 years. Dr. Tse is fully experienced in the research of cell biology, and he is mainly interested on cell division, cell polarity, cell adhesion and developmental biology. His researches are supporting by National Natural Science Foundation of China (NSFC) and Shenzhen Science, Technology and Innovation Commission (SZSTI).
My lab is mainly interested in cell biology researches. We particularly interested in study cytokinesis, cell adhesion, cell migration and related developmental process. Currently, we use nematode C. elegans and cultured human cells as the model systems and combine with live cell imaging, genetics and biochemistry to address the following problem:
(1) What is the molecular mechanism of cytokinesis?
(2) How does extracellular matrix regulate cytokinesis?
(3) What is the molecular mechanism of cell adhesion and its related developmental process?
(4) What is the molecular mechanism of cell migration?
2013 – Present Associate Professor, South University of Science and Technology of China, Department of Biology, Shenzhen, China,
2012 Postdoctoral Scholar, Division of Life Science, Hong Kong University of Science and Technology, Hong Kong;
2007 – 2012 Postdoctoral Fellow, Department of Molecular Genetics and Cell Biology, University of Chicago, USA.
2007 Ph.D., Biology, The Chinese University of Hong Kong, Hong Kong
2003 M. Phil., Molecular Biotechnology , The Chinese University of Hong Kong, Hong Kong
2001 B.Sc., Molecular Biotechnology, The Chinese University of Hong Kong, Hong Kong
1.Basant A, Lekomtsev S, Tse YC, Zhang D, Longhini KM, Petronczki M, Glotzer M. (2015) Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane. Developmental Cell 33: 204-215
2.Tse YC, Werner ME, Longhini MK, Labbe JC, Goldstein B, Glotzer M. (2012) RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4. Molecular Biology of the Cell 23: 4023-4031.
3.Tse YC, Wang J, Jiang L. (2012) Multivesicular bodies in developing tobacco seed and mung bean are functionally equivalent. Plant Signaling & Behavior 7:1-4.
4.Tse YC, Piekny A, Glotzer M. (2011) Anillin promotes astral microtubule-directed cortical myosin polarization. Molecular Biology of the Cell 22:3165-3175.
5.Wang J, Tse YC, Hinz G, Robinson DG, Jiang L. (2011) Storage globulins pass through the Golgi apparatus and multivesicular bodies in the absence of dense vesicle formation during early stages of cotyledon development in mung bean. Journal of Experimental Botany 63:1367-1380.
6.Afshar K, Werner ME*, Tse YC*, Glotzer M, Gönczy P. (2010) Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Development 137:237-47. (* these authors contributed equally to this work.)
7.Wang H, Tse YC, Law AH, Sun SS, Sun YB, Xu ZF, Hillmer S, Robinson DG, Jiang L. (2010) Vacuolar sorting receptors (VSRs) and secretory carrier membrane proteins (SCAMPs) are essential for pollen tube growth. The Plant Journal 61:826-838.
8.Tse YC, Lam SK, Jiang L. (2009) Organelle identification and characterization in plant cells: Using a combinational approach of confocal immunofluorescence and electron microscope. Journal of Plant Biology 52:1-9.
9.Lam SK, Cai Y, Tse YC, Wang J, Law AH, Pimpl P, Chan HY, Xia J, Jiang L. (2009) BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. The Plant Journal 60:865-881.
10.Lam SK, Tse YC, Miao Y, Li HY, Wang J, Lo SW, Jiang L. (2007) Molecular characterization of plant prevacuolar and endosomal compartments. Journal of Integrative Plant Biology 49:1119-1128.
11.Lam SK, Tse YC, Robinson DG and Jiang L. (2007) Tracking down the elusive early endosome. Trends in Plant Science 12: 497-505.
12.Tse YC, Lam SK and Jiang L. (2007) Enigmatic Brefeldin A. Plant Signaling & Behavior. Plant Physiology 2: 199-202.
13.Tse YC, Lo SW, Hillmer S, Dupree P and Jiang L. (2006) Dynamic response of prevacuolar compartments to Brefeldin A in plant cells. Plant Physiology 142:1442-1459.
14.Oliviusson P, Heinzerling L, Hillmer S, Hinz G, Tse YC, Jiang L and Robinson DG. (2006) Plant retromer: identification, localization to the prevacuolar compartment and microvesicles, and preliminary evidence for an interaction with vacuolar sorting receptors. Plant Cell 18:1239-1252.
15.Tse YC*, Mo BX* and Jiang L. (2006) Plant prevacuolar/endosomal compartments. International Review of Cytology 253:95-129. (* these authors contributed equally to this work.)
16.Fung KL, Yim YF, Tse YC, Miao Y, Sun SSM and Jiang L. (2005) Targeting and processing of membrane-anchored YFP fusion proteins to protein storage vacuole in transgenic tobacco seeds. Seed Science Research 15:361-364.
17.am SK, Tse YC, Jiang L, Oliviusson P, Heinzerling L and Robinson DG. (2005) Plant prevacuolar compartments and endocytosis. In “Plant Endocytosis” Samaj, J., Baluska, F. and Menzel, D. (eds) Plant Cell Monographs 1:37-61.
18.Tse YC, Mo B, Zhao M, Robinson DG, Hillmer S, Lo SW and Jiang L. (2004) Identification of multivescular bodies as prevacuolar compartments in Nicotiana tabacum BY-2 cells. Plant Cell 16:672-693.
19.Jin JB, Bae H, Kim SJ, Jin YH, Goh CH, Kim DH, Lee YJ, Tse YC, Jiang L and Hwang I. (2003) The Arabidopsis dynamin-like proteins ADL1C and ADU1E play a critical role in mitochondrial morphogenesis. Plant Cell 15:2357-2369.
20.Mo B, Tse YC and Jiang L. (2003) Organelle identification and proteomics in plant cells. Trends in Biotechnology 21:331-332.
21.Li YB, Rogers SW, Tse YC, Lo SW, Sun SSM., Jauh GY and Jiang L. (2002) BP-80 and homologs are concentrated on post-Golgi, probable lytic prevacuolar compartments. Plant & Cell Physiology 43:726-742.
22.Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, Fung KP, Lee CY, Waye MM. (2002) Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Science. 71:2267-2277.