GUO Chen
Research Assistant Professor

Research Interests

◆The role and potential mechanism of islet factor in gastrointestinal tumor

◆The role and potential mechanism of cell adhesion proteins in glomerular disease


Professional Experience

◆ 2018-Present Research assistant professor at Southern university of science and technology

◆ 2015-2017  Postdoc researcher at Southern university of science and technology


Educational Background

◆ 2012-2015    Peking University       Ph.D. in Biochemistry and molecular biology

◆ 2010-2012    Chonnam National University(Korea) M.A. in Molecular medicine

◆ 2006-2010    Dalian University        B.A. in Bioengineering


Selected Publication

  • Chen Guo, Guan Li, Jianing Hou, Xingming Deng, Sheng Ao, Zhuofei Li, Guoqing Lyu. Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer. Chin J Cancer Res. 2018 Dec; doi: 10.21147/j.issn.1000-9604.2018.06.11
  • Sun Y#*, Guo C#, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. Kindlin-2 association with RhoGDIα suppresses Rac1 activation and podocyte injury. J Am Soc Nephrol. 2017 Aug 3; pii: ASN.2016091021.
  • Guo Chen, Jianing Hou, Sheng Ao, Xingming Deng, Guoqing Lyu: HOXC10 up-regulation promotes gastric cancer cell proliferation and metastasis through MAPK pathway. Chin J Cancer Res. 2017 Dec;29(6):572-580. doi: 10.21147/j.issn.1000-9604.2017.06.12.
  • Wang Yang, Li Yuejiao, Guo Chen, Lu Qin, Wang Wweiping, Jia Zhuqing, Chen Ping, Ma Kangtao, Reinberg D, Zhou Chunyan*: ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Nucleic Acids Res. 2016 Aug 19;44(14):6741-55.
  • Guo Chen, Wang Weiping, Shi Qiong, Chen Ping, Zhou Chunyan*:Abnormally expressed ISL-1 represents a potential prognostic factor in gastric cancer. Hum Pathol. 2015 Sep;46(9):1282-9.
  • Hong Chang-Soo, Oh Jeong, Piao Zhengri, Guo Chen, Jung Mi-Ran, Choi Chan, Park Young-Kyu*: HOXB5 induces invasion and migration through direct transcriptional upregulation of B-catenin in human gastric carcinoma. Biochemical Journal. 2015 Dec 15;472(3):393-403.

Zhang Qiao, Yang Zhe, Jia Zhuqing, Liu Cuiling, Guo Chen, Lu Huafei, Chen Ping, Ma Kangtao, Wang Weipinh, Zhou Chunyan*: ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex. Molecular cancer 2014, 13:181.



Department of Biology

Southern University of Science and Technology

No 1088, Xueyuan Rd., Xili, Nanshan District,

Shenzhen, Guangdong, China