Dr. He Junlong was born in Malaysia and is currently a research associate scientist in the Department of Biomedical Engineering at Southern University of Science and Technology. His research focuses on the use of synthetic biology and protein engineering to address a variety of health and environmental issues, including the creation of a platform that allows researchers to share and systematically collect genetic structures for protein engineering purposes. In 2013, he received a Ph.D. in Biochemistry from Nanyang Technological University, Singapore. He studied under Professor Liang Zhao-xun, and used multi-module polyketide synthase to produce secondary metabolites, and designed proteins as biosensors for tracking bacterial intracellular signaling molecules. Cyclic di-GMP internal level of scientific research. He then worked as a postdoctoral researcher at the Synthetic Biology Clinical and Technical Innovation Center (SynCTI) at the National University of Singapore, focusing on protein design that confers therapeutic functions on probiotics and symbiotic microbes. The research results have been published in the journals of Nature Biomedical Engineering, Journal of American Chemistry Society, and ACS Synthetic Biology, and have been cited for more than 150 times. Two patents have been applied.
2008 – 2013 Nanyang Technological University, Singapore School of Life Sciences, Ph.D. in Biochemistry
2003 – 2006 Bachelor of Science, School of Science and Technology, University of Sabah, Malaysia BSc (Hons)
2018 – present Research Associate Scientist, Department of Biomedical Engineering, Southern University of Science and Technology
2014 – 2018 Researcher and Head of Treatment Research, Synthetic Biology Clinical and Technical Innovation Center (SynCTI), National University of Singapore, Yang Yuling Medical College
2013 – 2013 Project Manager, School of Chemistry and Biomedical Engineering, Nanyang Technological University, Singapore
2012 – 2013 Project Manager, School of Life Sciences, Nanyang Technological University, Singapore
Honors and Awards
2008 Nanyang Technological University Doctoral Research Scholarship
1. Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Thiery JP, Chang MW. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Nature Biomedical Engineering, 2018, 2, 27 -37
2. Lubkowicz D*, Ho CL*, Lee YS, Chang MW. Reprogramming probiotic Lactobacillus reuteri as a biosensor for detecting Staphylococcal quorum sensing. ACS Synthetic Biology., 2018 DOI: 10.1021/acssynbio.8b00063 (* all authors contributed equally)
3. Hoang LP*, Ho CL*, Wong Adison*, Lee YS, Chang MW. Applying the design-build-test paradigm in microbiome engineering. Current Opinion in Biotechnology, 2017, 48, 85-93 (* all authors contributed equally )
4. Ho CL, Hwang IY, Loh K, Chang MW. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin. MedChemComm, 2015, 6, 486-491
5. Ho CL, Chong KSJ, Akosua JO, Chuah MLC, Tan SM, Liang ZX. Visualizing the Perturbation of Cellular Cyclic di-GMP Levels in Bacterial Cells. Journal of the American Chemical Society, 2013, 135 (2), pp 566 –569
6. Ho CL, Koh SL, Chuah MLC, Luo Z, Tan WJ, Low DKS, Liang ZX. Rational Design of Fluorescent Biosensor for cyclic di-GMP. Chembiochem: a European journal of chemical biology., 2011, 12(18) :2753-8
7. Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, Chang MW. Reprogramming Microbes to Be Pathogen-Seeking Killers. ACS Synthetic Biology., 2013, DOI: 10.1021/sb400077j
8. Rasouliha BH, Ling H, Ho CL, Chang MW. A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa. Chembiochem: a European journal of chemical biology., 2013, DOI: 10.1002/cbic.201300410
9. Sun H, Ho CL, Ding F, Soehano I, Liu XW, Liang ZX. Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase. Journal of the American Chemical Society. 2012; 134(29):11924 -7.
10. Qi Y, Xu LH, Dong XM, Yau YH, Ho CL, Koh SL, Shochat SG, Chou SH, Tang K, Liang ZX. Functional Divergence of FimX in PilZ binding and Type IV Pili Regulation. Journal of bacteriology.
11. Lim J, Kong R, Murugan E, Ho CL, Liang ZX. Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8. PloS one. 6(6):e20549.