JIN Wenfei
Associate Professor

Dr. Wenfei Jin is an Associate Professor (PI ) in Department of Biology in Southern University of Science and Technology (SUSTech). He has worked on population genetics and precision medicine related field since his Ph.D. program. He has published >20 research articles and book chapters, including first/co-first author articles on Nature, AJHG, Genome Res, Genome Biol and HMG. He and his colleagues developed single cell DNase-seq that provides key regulatory information for precision medicine (Jin, et.al, 2015 Nature). Dr. Jin is interested in 1) single cell sequencing and its applications in cancer biology; 2) identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine. Dr. Wenfei Jin received his bachelor’s degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology in National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. He joined in SUSTech in 2017. Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation.

Research Interests
Dr. Jin’s lab is interested in identifying genetic/epigenetic changes underlying cancer, and developing disease risk prediction model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies.

Professional Experience
Mar.2017-present Associate Professor, Southern University of Science and Technology
Jan.2013-Mar.2017 Postdoc Fellow, National Institutes of Health (NIH) Mentor: Dr. Keji Zhao
Jan.2012-Dec.2012 Assistant Researcher, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB), SIBS, CAS
Educational Background
Sept.2006-Jan.2012 Ph.D. in Computational Biology, PICB and University of Chinese Academies of Sciences Supervisors: Prof. Felix Li Jin (CAS member) and Dr. Shuhua Xu
Feb.2006-April.2006 Intern, Institute of Biochemistry and Cell Biology, SIBS, CAS Mentors: Prof. Mofang Liu and Prof. Enduo Wang (CAS member)
Sept.2001-July.2006 B.Sc. in Biotechnology, Zhengzhou University, China

Honors & Awards
2017 Distinguished Scientist Award, NIH-CSSA
2016 Orloff Award (Single cell DNase-seq), NHLBI, USA
2016 Fellows Award for Research Excellence (FARE), NIH, USA
2014 Springer Theses, Springer
2013 Excellent Doctoral Dissertation, Chinese Academy of Sciences
2012 First-author Award, PICB
2012 Outstanding Graduate Award, University of Chinese Academy of Sciences
2012 SIBS-Eli Lilly Outstanding Graduate Thesis, Eli Lilly
2011 Travel Awards, 12th International Congress of Human Genetics (ICHG)/61th ASHG
2011 Pfizer Awards, Shanghai Institutes for Biological Sciences,CAS
2010 Di’ao scholarship Awards, Chinese Academy of Sciences

Selected Publication (#equal contribution)
[1] Jin W, Tang Q, Wangsa D, Cui K, Ried T and Zhao K. TrAC-looping reveals extensive reorganization of enhancer-promoter interaction during T cell activation. Cell (Under review)
[2] Ren G#, Jin W#, Cui K#, Rodrigez J, Larson D and Zhao K. 2017 CTCF-mediated enhancer-promoter interaction is a critical regulator of cell-to-cell variation of gene expression. Mol Cell. (In press)
[3] Jin W#, Tang Q#, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka T, Childs R, Levens D, Zhao K. 2015. Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature. 528:142-146
[4] Kraushaar DC#, Jin W#, Maunakea A, Abraham B, Ha M, Zhao K. 2013. Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 14:R121.
[5] Jin W#, Li R#, Zhou Y, Xu S. 2014. Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Euro J Hum Genet. 22:930-937.
[6] Wang E#, Jin W#, Duan W#, Qiao B, Sun S, Huang G, Shi K, Jin L, Wang H. 2013. Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population. PloS ONE. 8:e72423.
[7] Jin W, Xu S, Wang H, Yu Y, Shen Y, Wu B, Jin L. 2012. Genome-wide detection of natural selection in African Americans pre- and post-admixture. Genome Res. 22:519-527.
[8] Jin W, Wang S, Wang H, Jin L, Xu S. 2012. Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments. Am J Hum Genet. 91:849-862.
[9] Jin W, Qin P, Lou H, Jin L, Xu S. 2012. A systematic characterization of genes underlying both complex and Mendelian diseases. Hum Mol Genet. 21: 1611-1624.
[10] Xu S, Jin W, Jin L. 2009. Haplotype sharing analysis showing Uyghurs are unlikely genetic donors. Mol Biol Evol. 26: 2197-2206.

Books and Book Chapters
[1] Jin W. 2015. Admixture Dynamics, Natural Selection and Diseases in Admixed Populations. ISBN 978-94-017-7406-2. 114 Pages. Springer
[2] Xu S, Jin W. 2012. Population Genetics in the Genomic Era. Studies in Population Genetics, M. Carmen Fusté (Ed.). ISBN 978-953-51-0588-6. Intech.

1088 Xueyuan Avenue (Southern University of Science and Technology) # Faculty Research Building NO.1, Room 206
Shenzhen, Guangdong,518055 China

Other Info:
Please contact Dr. Wenfei Jin (jinwf@sustech.edu.cn) if you are interested in joining the lab.