LI Sisi


I received my PhD from Fudan University in 2013 and joined Dinshaw J. Patel’s lab in MSKCC to study the x-ray crystallography, with the emphasis on epigenetic regulators. We have complemented our structural efforts with functional studies undertaken by collaborators to deduce mechanistic insights into the biological systems of interest.

Research Interests

◆Structural study of gene regulators

Professional Experience

2017.02 — Present   Research Associate Professor  SUSTech
2016.02 — 2017.02  Senior Scientist  SUSTech
2013.06 — 2015.12  Research Fellow MSKCC

Educational Background

2007.09-2013.01  PhD Fudan University
2001.09-2005.06  BS  Jiangsu University

Honors & Awards

2012   National Scholarship
2012   Roche Diagnostics Scholarship

Selected Publication

1. Li S#, Yen L#, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ and Jacobsen SE. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. PNAS. 2016, 113: E5108-16.(# co-first author)

2. Höfer K#, Li S#, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ and Jäschke A. Structure and function of the bacterial decapping enzyme NudC. Nat Chem Biol. 2016, 12: 730-4.(# co-first author)

3. Chen YC, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Toth KF and Aravin AA. Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors. Mol Cell. 2016, 63: 97-109.

4. Shi X, Ran Z, Li S, Yin J and Zhong J. The Effect of MicroRNA bantam on Baculovirus AcMNPV Infection in Vitro and in Vivo. Viruses. 2016, 8: 136.

5. Li S, Patel DJ. Drosha and Dicer: Slicers cut from the same cloth. Cell Res. 2016 26: 511-2.

6. Li S, Yang Z, Du X, Gozani O, Jacobsen SE, Patel DJ and Du J. Structural basis for the unique combinatorial readout of unmodified H3 tail by Arabidopsis ORC1b BAH-PHD cassette. Structure. 2016 24: 486-94.

7. Webster A, Li S, Hur JK, Wachsmuth M, Bois JS, Perkins EM, Patel DJ, Aravin AA. Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Mol Cell. 2015 59: 564-75.

8. Kim B, Ha M, Loeff L, Chang H, Simanshu DK, Li S, Fareh M, Patel DJ, Joo C, Kim VN. TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. EMBO J. 2015 34:1801-15.

9. Le Thomas A, Stuwe E, Li S, Du J, Marinov G, Rozhkov N, Chen YC, Luo Y, Sachidanandam R, Toth KF, Patel D, Aravin AA. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 2014 28:1667-80.

10. Du J, Johnson LM, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol Cell. 2014 55: 495-504.

11. Li B, Li S, Yin J, Zhong J. Identification and characterization of the Spodoptera Su(var)3-9 histone H3K9 trimethyltransferase and its effect in AcMNPV infection. PLoS One. 2013 8: e69442

12. Li S, Du J, Yang H, Yin J, Ding J, Zhong J. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J.Mol.Cell Biol. 2013 5: 64-6.


◆ Rm 207, Wisdom Valley Block 4, SUSTech, Shenzhen, Guangdong, China
◆ Zip code: 518055
◆ Tel:0755-88018446
◆ Email: liss6@sustc.edu.cn