YUAN Xiaofei
Research Assistant Professor


Xiaofei Yuan received the Ph.D degree from the University of Tokyo (Japan) in 2005, working on protein-encapsulated drug delivery systems for cancer therapy, and obtained a patent on it during this period. As a postdoctoral researcher in Tsukuba University (Japan), Dr. Yuan focused on particle-based biosensors and developed highly sensitive immunolatex for Biokit S.A. biotechnology company (Spain) using special surface modification techniques, which extremely improved the detection limit of normal clinical immunolatex. After moving to University of Glasgow (UK), Dr. Yuan started microfabrication-based cross-disciplinary research related to Chemistry, Biology, Microbiology, and Environmental science. Apart from design and fabrication of 3D microfluidic prototypes for single-cell analysis for Nissan Chemical Industry Ltd. (Japan), Dr. Yuan was also involved in numbers of projects as co-applicants and published first-author papers in top journals.


Present Position
Research Assistant Professor, School of Environmental Science and Engineering, Southern University of Science and Technology


2002.10 - 2005.09:  Ph.D., Graduate School of Engineering, the University of Tokyo, Japan
2000.10 - 2002.09:  M.Sc., Graduate School of Engineering, the University of Tokyo, Japan
2000.04 - 2000.09:  Lab Research assistant, Graduate School of Engineering, the University of Tokyo, Japan
1998.10 - 2000.03:  Passed the highest Japanese level test, Yokohama International Education Academy, Japan
1992.09 - 1996.07:  B.Sc., Department of Applied Chemistry, Tianjin University, China


Work Experiences
2018.08 – Present:  Research Assistant Professor, School of Environmental Science and Engineering, Southern University of Science and Technology
2011.05 – 2018.08:  Senior Research Associate, Division of Biomedical Engineering, School of Engineering, University of Glasgow, UK
2005.10 – 2011.03:  Postdoctoral Researcher, Graduate School of Pure and Applied Sciences, University of Tuskuba, Japan


Mainly Involved Projects
[1]  Industrial Biotechnology Innovation Centre (IBioIC, Project-2016-152), Engineering microbial cell factories for industrial carotenoids biosynthesis, 2017.07-2018.10, project leader.
[2]  Natural Environment Research Council (NERC, NE/P003826/1), Stable Isotope Probing with Resonance Raman Cell Sorting to profile influence of ocean acidification on microbial carbon fixation, 2016.07-2017.07, project leader.
[3]  Engineering and Physical Sciences Research Council (EPSRC, EP/K038885/1), Reconstructing anaerobic synthetic communities to fuel bioenergy production using microfluidics, 2015.05-2016.06.
[4]  Nissan Chemical Industries, Ltd., Development of a continuous microfluidic – Raman sorting platform, 2013.10-2015.04, project leader.
[5]   Leverhulme Trust, Substrate control of cell shape and effect on gene expression, 2011.05-2013.04, project co-leaders.


Research Interests
[1]  Development of biosensors based on microfluidic techniques and/or microparticles.
[2]  Detection and treatment of aquatic environmental contaminants and pathogens.
[3]  Applications of microfluidic techniques in environmental microbe study.


Research ID: J-9581-2016
ORCid: 0000-0001-5395-9109
[1]  Xiaofei Yuan, Yanqing Song, Yizhi Song, Jiabao Xu, Yinhu Wu, Andrew Glidle, Maggie Cusack, Umer Z. Ijaz, Jonathan M. Cooper, Wei E. Huang, Huabing Yin*. Effect of laser irradiation on cell function and its implications in Raman spectroscopy. Applied and Environmental Microbiology, 2018, 84 (8), e02508-17. (SJR Q1, IF 3.81)
[2]  Xiaofei Yuan, Jillian M. Couto, Andrew Glidle, Yanqing Song, William Sloan*, Huabing Yin*. Single-cell microfluidics to study the effects of genome deletion on bacterial growth behavior. ACS Synthetic Biology, 2017, 6(12), 2219-2227. (SJR Q1, IF 5.38)
[3]  Kimberly C. Martin, Xiaofei Yuan, Gregory Stimac, Kieran Bannerman, Jamie Anderson, Chloe Roy, Fokion Glykofrydis, Huabing Yin, Jamie A. Davies*. Symmetry-breaking in branching epithelia: cells on micro-patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility. Journal of Anatomy, 2017, 230(6), 766–774. (SJR Q1, IF 2.18)
[4]  Elise Cachat, Weijia Liu, Kim. C. Martin, Xiaofei Yuan, Huabing Yin, Peter Hohenstein, Jamie A. Davies*. 2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation. Scientific Reports, 2016, 6, 20664. (SJR Q1, IF 4.26)
[5]  Xiaofei Yuan, Mi Zhou, Julie E. Gough, Andrew Glidle, Huabing Yin*. A novel culture system for modulating single cell geometry in 3D. Acta Biomaterialia, 2015, 24 (15), 228-240. (SJR Q1, IF 6.32)
[6]  Mi Zhou, Xiaofei Yuan, Huabing Yin, Julie E. Gough*. Restoration of chondrocytic phenotype on a two-dimensional micropatterned surface. Biointerphases, 2015, 10, 011003. (SJR Q2, IF 2.60)
[7]  Chunyan Li, Andrew Glidle, Xiaofei Yuan, Zhixiong Hu, Ellie Pulleine, Jon Cooper, Wantai Yang,* Huabing Yin*. Creating ‘Living’ polymer surface to pattern biomolecules and cells on common plastics. Biomacromolecules, 2013, 14, 1278-1286. (SJR Q1, IF 5.25)
[8]  Xiaofei Yuan, Dolça Fabregat, KeitaroYoshimoto, YukioNagasaki*. High PEGylation efficiency of pentaethylenehexamine-end poly(ethyleneglycol) (mPEG-N6) for active-ester surface. Colloids and Surfaces B-Biointerfaces, 2012, 92(1), 25-29. (SJR Q1, IF 3.89)
[9]  Xiaofei Yuan, Dolça Fabregat, KeitaroYoshimoto, YukioNagasaki*. Development of a high-performance immunolatex based on "soft landing" antibody immobilization mechanism. Colloids and Surfaces B-Biointerfaces, 2012, 99(1), 45-52. (SJR Q1, IF 3.89)
[10] Masaki Kubota, Keitaro Yoshimoto, Xiaofei Yuan, Yukio Nagasaki*. Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed-poly(ethylene glycol) tethered-chain layer. Polymer Journal, 2011,1-4. (SJR Q4, IF 2.15)
[11] Atsushi Hirano, Yutaka Maeda, Xiaofei Yuan, Ryuuichi Ueki, Yosuke Miyazawa, Junichi Fujita, Takeshi Akasaka, Kentaro Shiraki*. Controlled dispersion and purification of protein–carbon nanotube conjugates using guanidine hydrochloride. Chemistry-A European Journal, 2010, 16, 12221-12228. (SJR Q1, IF 5.32)
[12] Xiaofei Yuan, Dolça Fabregat, KeitaroYoshimoto, YukioNagasaki*. Efficient inhibition of interfacial nonspecific interaction to create practically utilizable high ferritin-response immunolatex. Analytical Chemistry, 2009, 81(24), 10097-10105. (SJR Q1, IF 6.32)
[13] Xiaofei Yuan, KeitaroYoshimoto, YukioNagasaki*. High-performance immunolatex possessing a mixed-PEG/antibody co-immobilized surface: High sensitive ferritin immunodiagnostics. Analytical Chemistry, 2009, 81(4), 1549-1556. (SJR Q1, IF 6.32)
[14] Xiaofei Yuan, Michihiro Iijima, Motoi Oishi, Yukio Nagasaki*. Structure and activity assay of nanozymes prepared by the co-immobilization of practically useful enzymes and hydrophilic block copolymers on gold nanoparticles. Langmuir, 2008, 24(13), 6903-6909. (SJR Q1, IF 3.83)
[15] Xiaofei Yuan, Yuichi Yamasaki, Atsushi Harada, Kazunori Kataoka*. Characterization of stable lysozyme-entrapped polyion complex (PIC) micelles with crosslinked core by glutaraldehyde. Polymer, 2005, 46(18), 7749-7758. (SJR Q1, IF 3.68)
[16] Xiaofei Yuan, Atsushi Harada, Yuichi Yamasaki, Kazunori Kataoka*. Stabilization of lysozyme-incorporated polyion complex (PIC) micelles by the -end-derivatization of poly (ethylene glycol)-poly (,-aspartic acid) block copolymers with hydrophobic groups. Langmuir, 2005, 21(7), 2668-2674. (SJR Q1, IF 3.83)
[17] Montree Jaturanpiny, Atsushi Harada, Xiaofei Yuan, Kazunori Kataoka*. Preparation of bionano-reactor based on core-shell structured polyion complexs micelles entrapping trypsin in the core cross-linked with glutaraldehyde. Bioconjugate Chemistry, 2004, 15, 344-348. (SJR Q1, IF 4.82)
Peer-reviewed Proceeding Papers
[18] Xiaofei Yuan, Chim Yahua, Huabing Yin*. Linking cell shape, elasticity and fate: In vitro re-differentiation of chondrocytes. Optical Elastography and Tissue Biomechanics (89460M), San Francisco, CA, USA, 2014.02.1-02.2.
Book Chapters
[19] Xiaofei Yuan, Dolça Fabregat, KeitaroYoshimoto, Yukio Nagasaki, Biomaterials (ACS Symposium series), Chapter 13: Design of highly functional antiferritin-Immunolatex by hybridization of antiferritin/mixed-PEG polymers onto polystylene submicroparticles. ACS publications, 2010,1054, 243-258.
[20] Xiaofei Yuan, Yukio Nagasaki. Current Technologies of Development and Application of Enzyme,Chapter 6:Preparation of PEG/enzyme co-immobilized gold nanoparticles and their function. CMC Publishing Co., Ltd., 2006, 275-281. (in Japanese)
[21] Kazunori Kataoka, Yuichi Yamasaki, Xiaofei Yuan, Atsushi Harada, Montree Jaturanpiny. Stabilized polymer micelles. 2004,12.09, Japan, WO2004105799.
[22] Yukio Nagasaki, Xiaofei Yuan, Keitaro Yoshimoto. Construction of immunolatex possessing antibody/mixed-poly(ethylene glycol) co-immobilized surface). patent # 2009-007846.
[23] Yukio Nagasaki, Xiaofei Yuan, Motoi Oishi, Michihiro Iijima. Poly(ethylene glycol)/glucose dehydrogenase co-immobilized gold surface. patent # 2008-010589.
[24] Huabing Yin, Xiaofei Yuan, Andrew Glidle. A hydrodynamic focusing method and related device. 2016, UK, WO201655646A1.