师资

刘晓羽
研究助理教授
0755-88010583
liuxy9@sustech.edu.cn

刘晓羽: 香港中文大学生物医学博士,曾任职于深圳华大基因研究院、香港中文大学生物医学学院、江南大学医学院。2019年10月起于南方科技大学医学院任研究助理教授。从事肿瘤细胞周期、凋亡及自噬的机制研究,近五年在Autophagy(2014)、Cell Death & Disease(2019)、Biochim Biophys Acta Mol Basis Dis(2018)、Biochem Pharmacol(2019)等SCI杂志发表研究论文7篇。

 

研究领域:

从事肿瘤细胞周期,凋亡及自噬方面的机制研究。主要从Ca2+稳态调控的角度研究细胞癌变的分子机制,解析Ca2+相关蛋白在肿瘤细胞增殖,转移,细胞自噬及细胞周期调控等方面的功能

 

学术成果:

  1. Liu X, Zhang P, Xie CM, et al. Activation of PTEN by inhibition of TRPV4 suppresses colon cancerdevelopment [J]. Cell death and disease, 2019Jun 12;10(6):460 .
  2. Liu X, Wang T, Wang Y, et al. Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers[J].Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2018, 1864(4): 975-986.
  3. Liu X, Wan X, Kan H, et al. Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis[J]. European journal of pharmacology, 2018, 832: 1-10 .
  4. Liu X, Han X, Wan X, et al. SPZ1 is critical for chemoresistance and aggressiveness in drug-resistant breast cancer cells[J]. Biochemical pharmacology, 2018, 156: 43-51.
  5. Zhang P*, Liu X*, Li H, Chen Z, Yao X, Jin J, Ma X. TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Scientific Reports. 2017 Jun 9;7(1):3158. (* Co-first author)
  6. Xie CM*, Liu XY*, Sham KW, Lai JM, Cheng CH. Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells. Autophagy. 2014; 10:0-13 (* Co-first author)
  7. Qing Chao*, Xiao-Yu Liu*, Ying-Chang Mei, Zhi-Fang Gao, Yi-Bo Chen, Chun-Rong Qian, Yu-Bo Hao, Bai-Chen Wang. Light-regulated phosphorylation of maize phosphoenolpyruvate carboxykinase plays a vital role in its activity. Plant Mol Biol. 2014; 85: 95-105 (* Co-first author)
  8. Xie CM, Liu XY, Yu S, Cheng CH. Cardiac glycosides block cancer growth through HIF-1α and NF-κB mediated Plk1. Carcinogenesis. 2013; 34:1870-80.
  9. Liu XY, Wu YD, Shen ZY, Shen Z, Li HH, Yu XM, Yan XF, Guo CH, Wang BC. Shotgun proteomics analysis on maize chloroplast thylakoid membrane. Front Biosci. 2011; 3: 250-5.
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