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傅暘
长聘副教授、博士生导师
0755-88015572
fuy@sustech.edu.cn
个人主页

个人简介

傅暘，博士，南方科技大学医学院生物化学系正高级研究员/长聘副教授，博士生导师，国家海外高层次青年人才，深圳市孔雀人才。现任南方科技大学生物安全平台副主任、深圳市科创委新药与疫苗专委委员。2013年获南开大学生物化学与分子生物学博士学位、哈佛大学医学院联合培养微生物学博士（2008-2013）。师从世界著名微生物学家、美国科学院院士John Mekalanos教授。

2019年于南科大独立建组以来，傅暘团队的科研工作方聚焦一个核心即细菌源性的大分子跨膜递送系统，着眼其系统激活及动态作用机理、效应蛋白作用机制、遗传元件的功能解析、原核互作与真核互作等面向，深入研究理论基础并桥接应用转化方向；同时，课题组基于在病原微生物学的长期积淀也响应国家与深圳市号召开展部分新冠与猴痘病毒等新发突发传染病病原的应急攻关研究。

我们鲜明研究特色是以革兰氏阴性细菌VI型分泌系统(T6SS)、胞外注射器(eCIS)两类典型的‘注射式分泌体统’为对象开展：1）精准抗菌机制与机理；2）细胞水平蛋白质精准递送；3）合成生物学应用技术研究。目前傅暘团队累计发表研究论文39篇（南科大31篇)，以通讯作者或第一作者身份发表，Cell Host & Microbe (3篇), Mol Cell, PNAS, Gut Microbes, Advanced Functional Materials, J Biol Chem(2篇), Microbiol Res (2篇)，mLife等高水平研究论文21篇。论文总引超5700次。申请技术发明专利7项，并已成功实现产业转化300万元。

本团队累计主持国家自然科学基金委面上项目和青年项目、中组部、广东省、深圳市科创委基础研发重点专项、深圳市科创委孔雀团队项目、深圳市抗疫应急攻关重点专项、深圳市医学科学院（SMART）等二十余项项目，科研经费充足。


学术任职

1、Bio-Protocol杂志编辑

2、Frontiers Cellular and Infection Microbiology专刊编辑

 

获奖荣誉

1、国家级人才头衔

2、深圳市人才头衔

3、Fogarty Global Health Fellowship

 

教育经历

1、2001.09-2005.06 江南大学，生物工程学专业学士

2、2006.09-2013.06 南开大学，生物化学与分子生物学专业博士

3、2009.09-2013.05 哈佛大学，微生物学与免疫生物学专业联培博士

 

工作经历：

1、2005.07-2006.08 南开大学，技术员

2、2008.06-2009.01 哈佛大学公共卫生学院，交换生

3、2013.07-2018.06 哈佛大学医学院，博士后研究员

4、2018.07-2019.06 哈佛大学医学院，助理研究员

5、2019.06-2020.12 南方科技大学，助理教授/博士生导师

6、2021.01-至今    南方科技大学，副教授/博士生导师

 

已发表论文：

* Contributed equally to the work and # for corresponding authors

Representative papers at SUSTech as a Corresponding author:

  1. Liu M, Wang H, Wang Z, Wang H, Zhang K, Xue J, Liu R, Liu Y, Xia P, Wang H, Kan B, Li Y, Li S, Fu Y#. A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics. Cell Host and Microbe. 2025; 33(7): 1146-1160. e8.

  2. Liu RH*, Zhang K*, Feng QS, He SJ, Fan QY, Zhang X, Li W, Bao ZP, Lin WF, Fu Y#, Li Y#. Unveiling Acidophilic Secretin Nanopores for Ion Exclusion and Single-molecule Sensing. Advanced Functional Materials. 2025, in press.

  3. Wang H, Liu Y, Wang Z, Xia P, Li Z, Liu M#, Fu Y#. Functional Insights into the Type VI Secretion System of Multi-drug Resistant Aeromonas hydrophila: A Key Factor in Competition and Pathogenesis. mLife. 2025; 4(4): 363-377.

  4. Guo HH, Zhang Q, Wang Z, Zhang K#, Fu Y#. Structural insight into Vibrio cholerae EIIC Sugar Transporter Dimer Captured in a Substrate-Free Inward-facing State. Acta Biochimica et Biophysica Sinica. 2025; 57(x):1-8.

  5. Feng Q, Dai, X, Wu, Q, Zhang L#, Yang L#, Fu Y#. C-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. mSphere. 2025; e01026-24.

  6. Xiang Q, Wu J, Zhou Y, Li L, Tian M, Li G#, Zhang Z#, Fu Y#. SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. Microbiol Res. 2024; 282:127659.

  7. Feng Q, Zhou J, Zhang L, Fu Y#, Yang L#. Insights into the molecular basis of c-diGMP signalling in Pseudomonas aeruginosa. Crit Rev Microbiol. 2024; 50(1): 20-38.

  8. Yu B*, Lu Q*, Li J*, Cheng X*, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y#, Fu Y#, Zhang J#. Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J Biol Chem. 2024; 300(6): 107288.

  9. Zhang Y*, Wang D*, Xiang Q*, Hu X, Zhang Y, Wu L, Zhang Z, Wang Y, Zhao J, McCormick PJ, Fu J#, Fu Y#, Zhang J#, Jiang H#, Li J#. A potent neutralizing nanobodytargeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology. 2024; 589: 109925.

  10. Liu M*, Wang H*, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Wang H, Wang H, Fu Y#. The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression. Gut Microbes. 2023; 15(1): 2241204.

  11. Liu M*, Zhao MY*, Wang H, Wang ZH, Wang Z, Liu Y, Li YP, Dong T, Fu Y#. Pesticin-Like Effector VgrG3(cp) Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition. Microbiol Spectr. 2023; 11(1): e0426722.

  12. Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y#, Li S#. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022; 82(24): 4712-4726. e4717.

  13. Xiang Q, Li L, Wu J, Tian M, Fu Y#. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies. Microbiol Res. 2022; 258: 126993.

  14. Song X*, Li J*, Tian M*, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022; 298(2): 10148.

  15. Chen Y*, Wang S*, Huang J*, Fu Y, Wen J, Zhou C, Fu Y#, Liu L#. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc. 2021; 78(2): 199-207.

  16. Cai Q*, Huang D*, Ou P*, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z, He Q, Liu L#, Fu Y#, Chen J#. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020; 75(7): 1742-1752.


    Before joining SUSTech

  17. Fu Y*, Ho BT*, Mekalanos JJ#. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host and Microbe. 2018; 23(2): 274-281 e272.

  18. Ho BT*, Fu Y*, Dong TG, Mekalanos JJ#. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci USA. 2017; 114(35): 9427-9432.

  19. Fu Y, Waldor MK, Mekalanos JJ#. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host and Microbe. 2013; 14(6): 652-663.