个人简介：

陈默，医学院药理学系研究员、副教授、南方科技大学稳态医学研究院院长助理、博士生导师。入选国家级高层次青年人才项目，深圳市鹏城孔雀特聘专家。2013年于新加坡国立大学（National University of Singapore）获得博士学位，2014至2017年于新加坡国立大学从事博士后研究。2017至2023年于美国威斯康星大学麦迪逊分校（University of Wisconsin Madison）相继任博士后和研究员。主要研究方向聚焦于细胞生物学、脂质生物学、磷酸肌醇信号通路、糖脂代谢与相关疾病分子机制。主持国家自然科学基金项目、广东省基础与应用基础研究基金委员会区域联合基金项目、SMART深圳市医学研究专项资金项目、深圳市基础研究专项（自然科学基金）面上项目。代表性成果以通讯/第一作者（含共同）发表在Nature Cell Biology（四篇：2019、2020、2022、2025）、Trends in Cell Biology、Cell Death & Differentiation（两篇: 2014、2018）、Protein & Cell、Cell Death & Disease、BBA-Molecular and Cell Biology of Lipids、Oral Science and Homeostatic Medicine、Journal of Hazardous Materials、Methods in Molecular Biology等国际知名期刊及丛书上，累计发表论文30篇。

教育背景：

2009-08 至 2013-12 新加坡国立大学，生物学，博士

2005-09 至 2009-06 四川大学，生物技术，学士

工作经历：

2024-01至今           南方科技大学医学院药理学系，副教授

2023-04至 2023-12 南方科技大学医学院药理学系，助理教授

2022-07至 2023-03 美国威斯康星大学麦迪逊分校医学院, Senior Scientist

2019-09至 2022-07 美国威斯康星大学麦迪逊分校医学院, Associate Scientist

2017-07至 2019-09 美国威斯康星大学麦迪逊分校医学院, 博士后

2014-01至 2017-06 新加坡国立大学生物系，博士后

获奖情况及荣誉：

2015 新加坡心血管协会优秀青年学者奖励

2009-2013 新加坡国立大学全额奖学金

2009 四川省优秀大学毕业生

2007 国家奖学金

学术任职：

1. Oral Science and Homeostatic Medicine编委会委员

2. Experimental and Molecular Pathology编委会委员

3. Journal of Translational Internal Medicine青年编委

4. 中国药理学会抗炎免疫药理专业委员会第十三届委员会委员

5. 广东省药理学会神经药理专委会委员

研究领域：

本课题组主要利用生物化学、细胞生物学、分子生物学、质谱等多种方法来研究磷酸肌醇信号调控、物质运输、糖脂与效应蛋白的复合及生物学功能，了解脂质在细胞器中非膜结构上的定位以及作用机理，解析疾病中的糖脂代谢功能异常并以此为靶点开发新型药物。

发表论文： 

1. Hou, X., Ren, C., Jin, J., Chen, Y., Lyu, X., Bi, K., Carrillo, N.D., Cryns, V.L., Anderson, R.A., Sun, J.* & Chen, M.* Phosphoinositide signalling in cell motility and adhesion. Nature Cell Biology 27, 736-748 (2025).

2. Sun, J.* & Chen, M.* Navigating AKT-ivity across cellular compartments. Trends in Cell Biology (2025).

3. Zhou, B.#, Feng, Y.#, Liang, J., Lu, Z., Zhang, S., Wang, X., Zhang, R., Shuai, S., Wang, S.* & Chen, M.* Pip5k1a regulates mandibular homeostasis by orchestrating osteogenesis in mice. Oral Science and Homeostatic Medicine (2025).

4. Hou, X.#, Chen, Y.#, Zhou, B.#, Liu, F., Dai, L., Chen, C., Carrillo, N.D., Cryns, V.L., Anderson, R.A., Sun, J.* & Chen, M.* The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility. Protein & Cell (2025).

5. Hou, X.#, Chen, Y.#, Carrillo, N.D., Cryns, V.L., Anderson, R.A., Sun, J., Wang, S.* & Chen, M.* Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics. Cell Death & Disease 16, 296 (2025).

6. Chen, M.*, Tan, J.X., Sun, Y., Thapa, N., Cryns, V.L. & Anderson, R.A.* Agonist- and stress-driven compartmentalized phosphoinositide signaling in cells. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1870, 159662 (2025).

7. Ren, C.#, Liu, F.#, Li, X., Zhang, Y., Liu, X., Wang, J.*, Sun, J.* & Chen, M.* Decoding phosphoinositide signaling in viral pathogenesis and autoimmune disorders. Microbes & Immunity, in press (2025).

8. Ren, C., Carrillo, N.D., Cryns, V.L., Anderson, R.A. & Chen, M.* Environmental pollutants and phosphoinositide signaling in autoimmunity. Journal of Hazardous Materials 465, 133080 (2024).

9. Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J.H., Cryns, V.L.* & Anderson, R.A.* A p53-phosphoinositide signalosome regulates nuclear AKT activation. Nature Cell Biology 24, 1099-1113 (2022).

10. Thapa, N.#, Chen, M.#, Horn, H.T., Choi, S., Wen, T. & Anderson, R.A.* Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4. Nature Cell Biology 22, 1357-1370 (2020).

11. Choi, S.#, Chen, M.#, Cryns, V.L. & Anderson, R.A.* A nuclear phosphoinositide kinase complex regulates p53. Nature Cell Biology 21, 462-475 (2019).

12. Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G.D., Wu, M. & Ge, R.* Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs. Cell Death & Differentiation 25, 1905-1920 (2018).

13. Chen, M., Zhang, Y., Yu, V.C., Chong, Y.S., Yoshioka, T. & Ge, R.* Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death & Differentiation 21, 797-810 (2014).

14. Chen, M., Wen, T., Horn, H.T., Chandrahas, V.K., Thapa, N., Choi, S., Cryns, V.L. & Anderson, R.A.* The nuclear phosphoinositide response to stress. Cell Cycle 19, 268-289 (2020).

15. Chen, M., Horn, H.T., Wen, T., Cryns, V.L. & Anderson, R.A.* Assessing in situ phosphoinositide-protein interactions through fluorescence proximity ligation assay in cultured cells. Methods in Molecular Biology 2251, 133-142 (2021).

16. Thapa, N., Chen, M., Cryns, V.L.* & Anderson, R.A.* A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism. Cell Reports 43, 114119 (2024).

17. Lee, J.H., Chen, M.,  Wen, T., Anderson, R.A.* & Cryns, V.L.* Regulation of the MDM2-p53 nexus by a nuclear phosphoinositide and small heat shock protein complex. Journal of Biological Chemistry 301, 110527 (2025).

18. Wen, T., Chen, M., Cryns, V.L.* & Anderson, R.A.* The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers. Journal of Biological Chemistry 301, 110412 (2025).

19. Chen, C., Carrillo, N.D., Chen, M., Wen, T., Awasthi, P., Anderson, R.A.* & Cryns, V.L.* Regulation of NRF2 by stably associated phosphoinositides and small heat shock proteins in response to stress. Journal of Biological Chemistry 301, 110367 (2025).

20. Zhang, D., Li, S., Wang, Y., Zhang, Z., Xu, H., Wu, S., Jin, H., Han, X., Liu, Y., Wen, X., Wu, Y., Zhang, Z., Hu, L., Hu, L., Zhang, C., Wang, J., Yan, R., Chen, M., Xiao, G., Sun, G. & Wang, S.* Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance. Signal Transduction and Targeted Therapy, in press (2025).

（#共同一作，*通讯作者）