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姚青
研究助理教授
0755-88018488
yaoq@sustech.edu.cn

个人简介:

姚青,香港大学医学院博士,在美国密歇根大学医学院接受博士后训练。从博士期间起开始专注于骨骼发育与疾病的研究,感兴趣的领域包括软骨发育及软骨细胞代谢,骨骼发育中的缺氧机制和缺氧诱导因子HIFs的功能及作用机理,骨性关节炎中软骨细胞的代谢机制,软骨细胞中内质网应激信号通路与缺氧信号通路的相互作用等。近五年内,在Developmental Cell, Bone Research 等著名SCI杂志发表研究论文数篇。曾受邀参加ASBMR (American Society for Bone and Mineral Research),The Frederick J. Fisher Pediatric Orthopaedic Lectureship等国际及专业会议做学术报告,并获得ASBMR 颁发的2017年青年研究学者荣誉。

 

教育背景:

2010.09-2015.02,香港大学,医学院,博士

2006.09-2009.06,中山大学,生命科学学院,硕士

2002.09-2006.06,华中师范大学,生命科学学院,学士

                                                      外国语学院,学士

 

工作经历:

2020.05-至今,    南方科技大学,医学院,助理研究教授

2015.05-2017.10, 美国密歇根大学,医学院,博士后研究员

2009.08-2010.08, 中山大学,生物工程中心,研究助理

 

获奖情况及荣誉:

ASBMR Young Investigator Award, 2015(美国骨与矿物研究协会,青年研究学者奖)

 

获得研究基金:

10/2016-10/2017   美国密歇根大学医学院,骨科专项研究基金

09/2020-08/2022   深圳市稳定支持计划面上项目基金  金额:50万元 人民币

                               题目:创伤后骨性关节炎发生早期关节软骨细胞代谢程序的改变

01/2022-12/2025   国家自然科学基金面上项目基金   金额:53万元 人民币

                               题目:线粒体转录因子A(TFAM)调节软骨细胞能量代谢终极分化的作用和机制


学术任职:

6/2016 – 至今 Medicine  审稿人,杂志学术编辑

6/2018 – 至今 Aging       审稿人

 

发表论文:

1. Yao Q., Parvez Khan M, Schipani E. “In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes.” Bone, 2020, 140(115572)

2. Yao, Q., Parvez Khan M, Merceron C, LaGory E, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E. “Suppressing mitochondrial respiration is critical for hypoxia tolerance in the fetal growth plate.” (2019) Developmental Cell,49:748-763 (Preview in the same issue of Developmental Cell; featured in the Editor’s Choice of Science Signaling 2019;12)

3. Merceron, C., Ranganathan, K., Wang, E., Tata, Z., Makkapati, S., Khan, M. P., Mangiavini, L., Yao, A. Q., Castellini, L., Levi, B., Giaccia, A. J., Schipani, E. “Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual.” (2019) Bone research, 7:7
4. Kudelko M., Chan C.W., Sharma R., Yao Q., Lau, E., Chu, I.K., Cheah, K.S.E., Tanner, J.A. and Chan, D. "Label-Free Quantitative Proteomics Reveals Survival Mechanisms developed by hypertrophic chondrocytes under ER stress." (2016) J.Proteome Res. 15(1):86-99
5. Pineault KM., Swinehart IT.,Garthus KN., Ho E., Yao Q., Schipani E., Kozloff KM.,Wellik DM. "Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation." (2015) Biol Open, 4(11),1538-1548
6. Zhang, Q. Q., H. Xu, M. B. Huang, L. M. Ma, Q. J. Huang, Yao, Q., H. Zhou, and L. H. Qu. "Microrna-195 Plays a Tumor-Suppressor Role in Human Glioblastoma Cells by Targeting Signaling Pathways Involved in Cellular Proliferation and Invasion." Neuro Oncol 14, no. 3 (2012): 278-87.
7. Yao, Q., H. Xu, Q. Q. Zhang, H. Zhou, and L. H. Qu. "Microrna-21 Promotes Cell Proliferation and Down-Regulates the Expression of Programmed Cell Death 4 (Pdcd4) in Hela Cervical Carcinoma Cells." Biochem Biophys Res Commun 388, no. 3 (2009): 539-42.
8. Zhang R, Yao Q, Peng JX, Hong HZ, (2006) “The Structure, Function and Evolution of Baculoviral Inhibitor of Apoptosis Gene.” Microbiology China. 0253-2654 (2006) 01-0128-05
9. Li JJ, Yao Q, Yang DY, Yu ZH, Chen XW, (2005) “Cloning and Expression of Ubiquitin Gene of Helicoverpa armigera Single-nucleocapsid Nucleopolyhedrovirus and its Antiserum Preparation.” Virologica Sinica. 20 (3): 298-302