WU Changfeng
Deputy Department Head

Lab website: http://wulab.bme.sustech.edu.cn/


2005-2008 Ph. D. in Chemistry, Clemson University
2001-2004 Ph. D. in Physics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, China
1998-2001 M. S. in Material Science, Jilin University, China
1994-1998 B. S. in Material Science, Qilu University of Technology, China


Work Experience
2016-now Professor of Biomedical Engineering, Southern University of Science and Technology
2012-2016 Professor of Biomedical Engineering College of Electronic Science and Engineering, Jilin University
2008-2012 Postdoctoral Fellow, Department of Chemistry, University of Washington
2004-2005 Postdoctoral Fellow, Department of Physics, Clemson University


Research Interests
Multifunctional probes for biomedical diagnostics and therapeutics
Fluorescent semiconductor polymer dots for biological imaging and sensing
Single molecule techniques for biomolecular dynamics and cellular processes
Photophysics of semiconducting polymers and lanthanide materials
Design/construction of spectroscopic and imaging instrumentation


Honors and Awards
2012 Outstanding Young Scholars of National Science Foundation of China
2008 Outstanding Graduate Researcher Award, Department of Chemistry, Clemson University
2007 Departmental Research Incentive Award, Department of Chemistry, Clemson University
2003 Da-Heng Optical Research Award, Chinese Academy of Sciences


Selected Publications

1.Zhang, Z.; Fang, X.; Liu, Z.; Liu, H.; Chen, D.; He, S.; Zheng, J.; Yang, B.; Qin, W.; Zhang, X.; Wu, C.*, Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging. Angewandte Chemie International Edition 2020, 59, 3691-3698.
2.Lei, C.; Chen, D.; Jiang, Y.; Zhang, J.; Yu, J.; DuFort, C.C.; Hingorani, S.R.; Zhang, X.; Wu, C.*; Chiu, D.T.*, A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features. Angewandte Chemie International Edition 2019, 58(21), 7008-7012.
3.Zhang, B.; Wang, F.; Zhou, H.; Gao, D.; Yuan, Z.; Wu, C.*; Zhang, X.*, Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy. Angewandet Chemie- International Edition 2019, 58(9), 2744-2748.
4.Chen, H.; Wang, F.; Liu, M.; Qian, M.; Men, X.; Yao, C.; Xi, L.; Qin, W.; Qin, G.*; Wu, C.*, Near-Infrared Broadband Polymer-Dot Modulator with High Optical Nonlinearity for Ultrafast Pulsed Lasers. Laser & Photonics Reviews 2019, 13(2), 1800326.
5.Sun, K.; Yang, Y.; Zhou, H.; Yin, S.; Qin, W.; Yu, J.; Chiu, D.T.; Yuan, Z.; Zhang, X.; Wu, C.*, Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone, ACS Nano 2018, 12 (6), 5176–5184
6.Chen, H.; Fang, X.; Jin, Y.; Hu, X.; Yin, M.; Men, X.; Chen, N.; Fan, C.; Chiu, D. T.; Wan Y.*; Wu, C.*, Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery. Small 2018, 14(21), 1800239.
7.Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters 2017, 17 (7), 4323-4329.
8.Chen, X.; Liu, Z.; Li R.; Shan, C.; Zeng, Z.; Xue, B.; Yuan, W.; Mo, P.; Xi, P.*; Wu, C.*; Sun, Y.*, Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots. ACS Nano 2017, 11 (8), 8084-8091.
9.Chen, X.; Li R.; Liu, Z.; Sun, K.; Sun, Z.; Chen, D.; Xu, G.; Xi, P.; Wu, C.*; Sun, Y.*, Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy. Advanced Materials 2017, 29 (5), 1604859.
10.Chen, D.; Wu, I. C.; Liu, Z.; Tang, Y.; Chen, H.; Yu, J.; Wu, C.*; Chiu, D. T.*, Semiconducting Polymer Dots with Bright Narrow-Band Emission at 800 nm for Biological Applications. Chemical Science 2017, 8 (5), 3390-3398.
11.Chen, H.; Zhang, J.; Chang, K.; Men, X.; Fang, X.; Zhou, L.; Li, D.; Gao, D.; Yin, S.; Zhang, X.; Yuan, Z.; Wu C.*; Biomaterials. 2017, 144, 42-52.
12.Chen, D.; Li, Q.; Meng, Z.; Guo, L.; Tang, Y.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Zhang, X.; Wu. C.*, Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver. Theranostics 2017, 7(7), 1820-1834.
13.Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang, X.; Wu, C.*, In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer. ACS Nano 2016, 10 (7), 6769-6781.
14.Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine. Angewandet Chemie- International Edition 2013, 52 (11), 3086-3109.
15.Yu, J.; Wu, C.; Zhang, X.; Ye, F.; Gallina, M. E.; Rong, Y.; Wu, I. C.; Sun, W.; Chan, Y. H.; Chiu, D. T., Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging. Advanced Materials 2012, 24 (26), 3498-3504.
16.Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for in Vivo Tumor Targeting. Angewandet Chemie- International Edition 2011, 50 (15), 3430-3434.
17.Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting. Journal of American Chemical Society 2010, 132 (43), 15410-15417.
18.Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry. Angewandet Chemie- International Edition 2010, 49 (49), 9436-9440.
19.Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging. Angewandet Chemie- International Edition 2009, 48 (15), 2741-2745.
20.Yu, J.; Wu, C.; Sahu, S. P.; Fernando, L. P.; Szymanski, C.; McNeill, J., Nanoscale 3D tracking with conjugated polymer nanoparticles. Journal of American Chemical Society 2009, 131(51), 18410-18414.
21.Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy transfer in a nanoscale multichromophoric system: fluorescent dye-doped conjugated polymer nanoparticles. Journal of Physical Chemistry C 2008, 112(6), 1772-1781.
22.Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging. ACS Nano 2008, 2 (11), 2415-2423.
23.Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging. Journal of American Chemical Society 2007, 129 (43), 12904-12905.
24.Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy transfer mediated fluorescence from blended conjugated polymer nanoparticles. Journal of Physical Chemistry B 2006, 110(29), 14148-14154.
25.Wu, C.; Szymanski, C.; McNeill, J., Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles. Langmuir 2006, 22(7), 2956-2960.