XIAO Guozhi
Recipient, Shenzhen Scholar Program

Professor Guozhi Xiao is an internationally renowned bone biologist. Dr. Xiao obtained his PhD degree in biochemistry and molecular biology from Peking University in 1994. He finished his post-doc training (1994-1998) and worked as a research scientist (1998-2005) at the University of Michigan Ann Arbor. In 2005, he assumed an independent faculty position as a tenure-track assistant professor at the University of Pittsburgh School of Medicine in 2005 and was promoted to the level of associate professor with tenure in 2011. In 2012, he joined Rush University Medical Center in Chicago and assumed a prominent academic position as the Dr. Ralph and Marian C. Falk Endowed Chair Professor of Biochemistry and served as the director of research of the department of biochemistry. In 2013, he joined the SUSTech as a tenured full professor and later became the chair of the biological department. Dr. Xiao is the director of the Center for Experimental Animals at SUSTech. Dr. Xiao is the dean of Zhicheng College at SUSTech. Dr. Xiao has made several contributions to our understanding the molecular control of skeletal development and homeostasis. His work is reported in more than 100 peer-reviewed publications, many in high profile journals such as the Journal of Clinical Investigation and Nature Communications. He serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and sits on the editorial boards of the Journal of Bone and Mineral Research (JBMR) and the Journal of Biological Chemistry (JBC). Dr. Xiao’s research interests focus in the following areas: (1) to determine how osteoblast, osteoclast, and chondrocyte formation is controlled during skeletal development and homeostasis under physiological and pathological conditions; (2) to define the mechanisms that modulate bone angiogenesis; and more recently, (3) to study the roles of focal adhesion (FA) proteins in skeletal development and homeostasis. By working on these projects, Xiao laboratory has also maintained a focus on important medical issues involving bone –osteoarthritis, osteoporosis, metastatic osteolytic lesions, and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.


Research Interests
My research focuses include: 1) mechanisms that control bone and cartilage development and homeostasis; 2) mechanisms of cancer bone metastases; 3) mechanisms that modulate bone angiogenesis during skeletal development and homeostasis; and 4) the role of cell adhesion molecules such as Kindlin-2 and migfilin in bone and cartilage. By working on these projects, I also maintain a focus on medical issues involving bone – osteoporosis, osteoarthritis and metastatic osteolytic lesions and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.


Educational background
1979-1984:Nanchang University School of Medicine, Bachelor Degree of Medicine.
1985-1988:Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Master Degree.
1991-1994: Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Ph.D.


Professional experience
2015-present: Chair, Department of Biology, Southern University of Science and Technology, Shenzhen
2013-present: Professor and Chair, Department of Biology, Southern University of Science and Technology, Shenzhen.
2011-2013: Associate professor, Director of Research, Ralph and Marian C. Falk Endowed Professor of Biochemistry of Rush University.
2005-2011: Assistant professor/Associate professor (with tenure), University of Pittsburgh School of Medicine.
1998-2005: Instructor/Research assistant professor, University of Michigan School of Dentistry (Ann Arbor).
1994-1998:Post doctor, University of Michigan School of Dentistry (Ann Arbor).


Honors & Awards
1998 ASBMR Young Investigator Award
2012 Outstanding Alumni, Beijing Medical University (Currently Peking University Health Sciences Center)
2013-present: Shenzhen Pengcheng Scholar
2017-present: Shenzhen Peacock Scholar


Professional Activities
Editorial Board Member:
2009-2015: Journal of Bone and Mineral Research (JBMR)
2010-present: Chinese Journal of Biochemistry and Molecular Biology
2011-present: Stem Cell Discovery
2013-present: Journal of Biological Chemistry (JBC)
2015-present: Chinese Journal of Family Planning


Selected Publications

From total 130 publications

  1. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.

  2. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.

  3. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.

  4. Frendo JL, Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.

  5. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res, 1999; 14:893-903.

  6. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.

  7. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459.

  8. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.

  9. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.

  10. Zhao M, Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451.

  11. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.

  12. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene: requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.

  13. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.

  14. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem, 2005; 280:30689-30696.

  15. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem, 2005; 280:30845-30855.

  16. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivoMol Ther. 2005; 12(2):247-53.

  17. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.

  18. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.

  19. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.

  20. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2007; 103(2): 434-46.

  21. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.

  22. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating 
transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.

  23. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy, BoneKEy is published by the International Bone & Mineral Society, link: http://www.bonekey-ibms.org/).

  24. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.

  25. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.

  26. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases
osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem.  2008; 283(9): 5542-53. PMCID: PMC2736298.

  27. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.

  28. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625

  29. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.

  30. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.

  31. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts, J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.

  32. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.

  33. Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.

  34. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.

  35. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.

  36. Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol.2013 Jul 15;191(2):857-64. PMCID: PMC3702632.

  37. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res. 2013;28: 1870–1884. PMID: 23649506. (This is an EDITOR'S CHOICE paper of September 2013 JBMR issue with a commentary. For a Commentary on this article, please see Schipani et al. (J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).

  38. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene 513 (2013) 101–110. PMCID: PMC3514579.

  39. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.

  40. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.

  41. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through iompaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.

  42. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.

  43. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.

  44. Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D. Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: 244312822.

  45. Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: 24578159.

  46. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719

  47. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol. Chem. 2015 Mar 27;290(13):8081-94. doi: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: 25648889

  48. Wu C, Jiao H, Lai Y, Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: 26151572

  49. Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B, Cheng T. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015 Nov 19;126(21):2383-91. doi: 10.1182/blood-2015-03-633354. Epub 2015 Sep 17. PMID: 26384355

  50. Zhu K, Song P, Lai Y, Xiao G. Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts. Gene. 2016 Dec 5;594(1):125-130. doi: 10.1016/j.gene.2016.09.011. PMID: 27614241.

  51. Kc R, Li X, Kroin JS, Liu Z, Chen D, Xiao G, Levine B, Li J, Hamilton JL, van Wijnen AJ, Piel M, Shelly DA, Brass D, Kolb E, Im HJ. PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth. Ann Rheum Dis. 2016 Dec;75(12):2133-2141.PMID: 26783110

  52. Zhang M, Yang H, Lu L, Wan X, Zhang J, Zhang H, Liu X, Huang X, Xiao G, Wang M. Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandiblar joint cartilage. Osteoarthritis Cartilage. 2017 May 19. pii: S1063-4584(17)30993-7

  53. Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X. Osteoblasts support megakaryopoiesis through production of interleukin 9. Blood.2017;129(24):3196–3209. doi:10.1182/blood-2016-11-749838.

  54. Zhang Y, Xu S, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, Ding C, Li M, Xiao G, Liu B, Liu A, Bai X. mTORC1 inhibits NF-kB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice. J Bone Miner Res, 2017 Sep;32(9):1829-1840.

  55. Sun Y*, Guo C, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. Kindlin-2 association with Rho GDP-Dissociation Inhibitor α suppresses Rac1 activation and podocyte injury. J Am Soc Nephrol. 2017 Dec;28(12):3545-3562.

  56. Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, Xiao G, Wu C. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. J Cell Biol. 2018 Apr 2;217(4):1431-1451. doi: 10.1083/jcb.201612177. Epub 2018 Mar 1. PMID: 29496737

  57. Wang T, Li S, Yi D, Zhou GQ, Chang Z, Ma PX, Xiao G, Chen D. CHIP Regulates Bone Mass by Targeting Multiple TRAF Family Members in Bone Marrow Stromal Cells. Bone Res. 2018 Mar 29;6:10. doi: 10.1038/s41413-018-0010-2. eCollection 2018. PMID: 29619270.

  58. Yang X, Xia R, Yue C, Zhai W, Du W, Yang Q, Cao H, Chen X, Obando D, Zhu Y, Chen X, Chen J, Piganelli J, Wipf P, Jiang Y, Xiao G, Wu C, Jiang J, Lu B. ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming. Cell Rep. 2018 May 8;23(6):1754-1766. doi: 10.1016/j.celrep.2018.04.032.

  59. Yi YS, Jian J, Gonzalez-Gugel E, Shi YX, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X, Xiao G, Chen L, Liu CJ. p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice. EBioMedicine. 2018 Mar;29:78-91

  60. Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Sep;25(9):1549-1566

  61. Chen H, Wang Y, Dai H, Tian X, Cui ZK, Chen Z, Hu L, Song Q, Liu A, Zhang Z, Xiao G, Yang J, Jiang Y, Bai X. Bone and plasma citrate is reduced in osteoporosis. Bone. 2018 Sep;114:189-197.

  62. Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y, Wu C. Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. 2019 Feb 19;10(1):845. doi: 10.1038/s41467-019-08772-3. PMID: 30783087

  63. Zhao L, Huang J, Fan Y, Li J, You T, He S, Xiao G, Chen D. Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis. Ann Rheum Dis. 2019 May;78(5):676-682. doi: 10.1136/annrheumdis-2018-214724. Epub 2019 Mar 6. PMID: 30842121

  64. Huang J, Zhao L, Fan Y, Liao L, Ma PX, Xiao G, Chen D. The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression. Nat Commun. 2019 Jun 28;10(1):2876. doi: 10.1038/s41467-019-10753-5. PMID: 3125384.

  65. Liu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei ZN, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen ZS, Liu CJ. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. Ann Rheum Dis. 2019 Nov;78(11):1524-1535. doi: 10.1136/annrheumdis-2019-215543. Epub 2019 Jul 13. PMID: 31302596

  66. Gao H, Guo Y, Yan Q, Yang W, Li R, Lin S, Bai X, Liu C, Chen D, Cao H, Xiao G. Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of Kindlin-2. JCI Insight. 2019 Jul 11;4(13).

  67. Cao H, Xiao G (2019): Kindlin Signaling and Bone. Encyclopedia of Bone Biology, Elsevier

  68. Wang Y, Yan Q, Zhao Y, Liu X, Lin S, Zhang P, Ma L, Lai Y, Bai X, Liu C, Wu C, Feng JQ, Chen D, Cao H, Xiao G. Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight. 2019 Nov 14;4(22). pii: 131692. doi: 10.1172/jci.insight.131692. PMID: 31723057.

  69. Cao H, Yan Q, Wang D, Lai Y, Zhou B, Zhang Q, Jin W, Lin S, Lei Y, Ma L, Guo Y, Wang Y, Wang Y, Bai X, Liu C, Feng JQ, Wu C, Chen D, Cao X, Xiao G. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Res. 2020 Jan 2;8:2. doi: 10.1038/s41413-019-0073-8. eCollection 2020. PMID: 31934494.

  70. Yang H, Wen Y, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Ye T, Bai X, Xiao G*, Wang M*. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.

  71. Feng X, Pan J, Li J, Zeng C, Qi W, Shao Y, Liu X, Liu L, Xiao G, Zhang H, Bai X, Cai D. Metformin attenuates cartilage degeneration in experimental osteoarthritis via the regulation of AMPK/mTOR. Aging (Albany NY). 2020 Jan 16;12. doi: 10.18632/aging.102635. [Epub ahead of print]. PMID: 31945013.

  72. Zhu K, Lai Y, Cao H, Liu C, Bai X, Yan Q, Ma L, Chen D, Kanaporis G, Wang J, Li L, Cheng T, Wang Y, Wu C, Xiao G. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun. 2020 Jan 24;11(1):484. doi: 10.1038/s41467-019-14186-y.PMID: 31980627.

  73. Chen S, Qin L, Wu X, Fu X, Lin S, Chen D, Xiao G, Shao Z and Cao H. Moderate fluid shear stress regulates heme oxygenase-1 expression to promote autophagy and ECM homeostasis in the nucleus pulposus cells. Front Cell Dev Biol. 2020 Mar 3;8:127. doi: 10.3389/fcell.2020.00127. eCollection 2020. PMID: 3219525

  74. Li J, Zhang B, Liu W, Lu K, Pan Ha, Wang T, Yi D, Huang J, Zhao L, Ning G, Xing C, Xiao G, Liu-Bryan, R, Feng S, Chen D. Metformin limits osteoarthritis development and progression through activation of AMPK signaling. Ann Rheum Dis. 2020 May;79(5):635-645. doi: 10.1136/annrheumdis-2019-216713. Epub 2020 Mar 10. PMID: 32156705

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  76. Shu B, Zhao Y, Zhao S, Pan H, Xie R, Yi D, Lu K, Yang J, Xue C, Huang J, Wang J, Zhao D, Xiao G, Wang Y, Chen D. Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation. Bone Res. 2020 Aug 12;8:31. doi: 10.1038/s41413-020-0104-5. eCollection 2020. PMID: 32821442.

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