GUO Hongwei
Chair Professor
Ten-thousand talents program

Dr. Hongwei Guo is a  distinguished professor and a chair professor at SUSTech. He is also the director of the newly established Institute of Nutrition and Food Safety (INFS). Dr. Hongwei Guo has devoted himself and his lab to the research field of plant molecular biology and genetics for decades. Particularly, his group had made great contributions to the understanding of plant ethylene signaling mechanisms. They have originally established theprotein degradation model and the RNA decay model for ethylene action, and revealed the crosstalk mechanisms between ethylene and other phytohomones(auxin, JA, and GA) and environmental factors (light, salt, and other stresses). Significant discoveries and findings from Guo’s lab were published in top peer-reviewed journals such as Cell, Nature, Science, PNAS, Plant Cell, Current Biology, among others. Consistent with his great scientific achievements and reputation, Dr. Guo also serves as standing committee member of AllChina Youth Federation, director of the youth work committee of Botanical Society of China, standing director of Botanical Society of China and Crop Science Society of China, reviewer of National Natural Science Foundation of China, and editorial board member of Mol Plant, PCP, JIPB and JGG.

Research Interests
◆Molecular mechanisms of ethylene signaling and crosstalk between plant hormones and environmental signals.
◆Regulation of plant development and senescence by plant hormones.
◆RNA decay, gene silencing, and their functions in plant hormone signaling.
◆Systemic investigation of plant hormone pathway evolution.

Professional Experience
◆2017 – present,Director,SUSTech-PKU Institute of Plant and Food Science
◆2016 – present, Chair Professor, Department of Biology, SUSTC.
◆2005 – 2015, Professor, School of Life Sciences, PKU.
◆2001-2005, Postdoc, Salk Institute, USA.

Educational Background
◆1996-2001, Ph.D., Cell and Developmental Biology, Department of Molecular, Cell and Development Biology, University of California, Los Angeles.
◆1992-1995, M.S., Department of Biotechnology, School of Life Sciences, Peking University.
◆1988-1992, B.S., Department of Biology, Nankai University.

Honors & Awards
◆2017 Peacock Talent plan A of Shenzhen
◆2016 Peacock Talent plan B of Shenzhen
◆2016 Local leading talent of Shenzhen City
◆2015 Youth Science and technology innovation leader
◆2014 Tan Jiazhen Life Science Innovation Award.
◆2013 Person of the Year (2012) by Scientific Chinese, China Association for Sciences and Technology.
◆2011 China Young Scientist Award, China Association for Sciences and Technology.
◆2009 China Excellent Youth Award (13th May-Fourth Medal).
◆2008 Outstanding Young Investigatorship, Chinese Society of Botany.
◆2007 Beijing Excellent Youth Award (22nd May-Fourth Medal).
◆2006 National Outstanding Young Investigator Award, NSF of China.
◆2006 Distinguished Professorship, Ministry of Education.

Selected Publication
1.Yichuan Wang*, Yusi Ji, Ying Fu and Hongwei Guo*, Ethylene-induced microtubule reorientation is essential for fast inhibition of root elongation in Arabidopsis. Journal of Integrative Plant Biology.
2.Xing Zhang, Yusi Ji, Chang Xue, Honghao Ma, Yulin Xi, Peixin Huang, Huan Wang, Fengying An, Bosheng Li, Yichuan Wang and Hongwei Guo*, Integrated Regulation of Apical Hook Development by Transcriptional Coupling of EIN3/EIL1 and PIFs in Arabidopsis. Plant Cell.
3.Cheng Zhang#, 1, Xiao-Dong Teng#, 1, Quan-Quan Zheng Yan-Yun Zhao, Jie-Yang Lu, Yichuan Wang, Hongwei Guo*, Zhong-Nan Yang*, Ethylene signaling is critical for synergid cell functional specification and pollen tube attraction. Plant Journal.
1.Feng Y., Xu P., Li B., Li P., Wen X., An Feng., Gong Yan., Xin Yi., Wang Y.*, Guo H.* (2017)., Ethylene Promotes Root Hair Growth through Coordinated EIN3/EIL1 and RHD6/RSL1 Activity in Arabidopsis. Proceedings of the National Academy of Sciences. 114(52):13834-13839.
2.Jiang B., Shi Y., Zhang X., Xin X., Qi L., Guo H., Li J., Yang S.(2017). PIF3 is a negative regulator of the CBF pathway and freezing tolerance in Arabidopsis. Proceedings of the National Academy of Sciences. 114(32):E6695-E6702.
3.Li Z., Woo H.*, Guo H.*,Hye Ryun.*(2017).Genetic redundancy of senescence- associated transcription factors in Arabidopsis. Journal of Experimental Botany. online publication.
4.Guo P., Li Z., Huang P., Li B., Fang S3., Chu J., Guo H.* (2017). A Tripartite Amplification Loop Involving the Transcription Factor WRKY75,Salicylic Acid and Reactive Oxygen Species Accelerates Leaf Senescence. Plant Cell.29(11):2854-2870.
5.Zhang X.,and Guo H.* (2017).mRNA decay in plants: both quantity and quality matter. Current Opinion in Plant Biology. 35:138-44.
6.Sun X., Li Y., He W.,Ji C.,Xia P., Wang Y., Du S., Li H, Raikhel N., Xiao J.*, Guo H.* (2017).. Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communations.8:15758.
7.Hao D., Sun X., Ma B., Zhang J.-S.* and Guo H.*(2017).6 – Ethylene. Hormone Metabolism and Signaling in Plants. J.Li, C. Li and S. M. Smith, Academic Press: 203-241.
8.Li Z. and Guo H.*. (2017). Ethylene treatment in studying leaf senescence in Arabidopsis. Methods in Molecular Biology: Plant Senescence (In Press).
9. Li Z., Zhao Y., Liu X., Jiang Z., Peng J., Jin J., Guo H.* and Luo J.*. (2017). Construction of the leaf senescence database and functional assessment of senescence-associated genes. Methods in Molecular Biology: Plant Genomics Databases.1533: 315-333.
1. Song W., Liu L., Wang J., Wu Z., Zhang H., Tang J., Lin G., Wang Y., Wen X., Li W., Han Z., Guo H.*, Chai J.* (2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Research. 26:674-85.
2. Li M., An F., Li W., Ma M., Feng Y., Zhang X., Guo H.* (2016). DELLA proteins interact with FLC to repress flowering transition. J Integr Plant Biol. 58:642-55.
3. Zhang X., Zhu Y., Wu H., Guo H.* (2016). Post-transcriptional gene silencing in plants: a double-edged sword. Sci China Life Sci. 59:271-6.
4. Zhu Z., Xian Z., Guo H.* Li Z.* (2016). Ethylene Biology Blooms from Fundamental Research to Postharvest Applications. Mol Plant. 9:187-8.
5. Qing D., Yang Z., Li M., Wong WS., Guo G., Liu S., Guo H., Li N. (2016). Quantitative and Functional Phosphoproteomic Analysis Reveals that Ethylene-Regulates Water Transport via the C-terminal Phosphorylation of Aquaporin PIP2;1 in Arabidopsis. Mol Plant. 9:158-74.
1. Li W., Ma M., Feng Y., Li H., Wang Y., Ma Y., Li M., An F., and Guo H.* (2015). EIN2-directed translational regulation of ethylene signaling in Arabidopsis. Cell, 163: 670-683.
2.Zhang X., Zhu Y., Liu X., Hong X., Xu Y., Zhu P., Shen Y., Wu H., Ji Y., Wen X., Zhang C., Zhao Q., Wang Y., Lu J. and Guo H.* (2015). Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis. Science, 348: 120-123.
3. Song J., Zhu C., Zhang X., Wen X., Liu L., Peng J., Guo H.*, Yi C.* (2015). Biochemical and Structural Insights into the Mechanism of DNA Recognition by Arabidopsis ETHYLENE INSENSITIVE3. PLoS One.10:e0137439.
1. Peng J., Li Z., Wen X., Li W., Shi H., Yang L., Zhu H. and Guo H.* (2014). Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Diminishing ROS Accumulation in Arabidopsis. PLoS Genetics, 10:e1004664
2. Zhang X., Zhu Z., An F., Hao D., Li P., Song J., Yin C., and Guo H.* (2014) Jasmonate-Activated MYC2 Represses ETHYLENE INSENSITIVE3 activity to antagonize ethylene-promoted apical hook formation in Arabidopsis. Plant Cell 26:1105-17.
3. Zhong S., Shi H., Xue C., Wei N., Guo H.* and Deng X.* (2014) An ethylene-orchestrated circuitry coordinates a seedling’s response to soil cover and etiolated growth. Proc. Natl. Acad. Sci. U S A, 111:3913-20. ( *Co-Corresponding)
4. Li Z., Zhao Y., Liu X., Peng J., Guo H.*, and Luo J.* (2014). LSD 2.0: an update of the leaf senescence database. Nucleic Acids Research, 42:D12000-5. ( *Co-Corresponding)
1.Li Z., Peng J., Wen X. and Guo H.* (2013). ETHYLENE-INSENSITIVE3 is a senescence-associated gene that accelerates age-dependent leaf senescence by directly repressing miR164 transcription in Arabidopsis. Plant Cell 25:3311-28
2.Zhang X, Chen Y, Lin X, Hong X, Zhu Y, Li W, He W, An F, Guo H.* (2013) Adenine Phosphoribosyl Transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis. Mol Plant. 6:1661-72
3.Song S, Qi T, Fan M, Zhang X, Gao H, Huang H, Wu D, Guo H, Xie D. (2013) The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-Mediated Plant Defense and Development. PLoS Genet. Jul;9(7):e1003653.
4.Ji Y and Guo H.* (2013). From endoplasmic reticulum (ER) to nucleus: EIN2 bridges the gap in ethylene signaling. Mol Plant. 6:11-4.
5.Zheng D, Han X, An Y, Guo H, Xia X, Yin W. (2013). The nitrate transporter NRT2.1 functions in the ethylene response to nitrate deficiency in Arabidopsis. Plant Cell Environ. Jan 11. doi: 10.1111/pce.12062.
6.Li H, Xu T, Lin D, Wen M, Xie M, Duclercq J, Bielach A, Kim J, Reddy GV, Zuo J, Benková E, Friml J, Guo H, Yang Z.(2013). Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis. Cell Res. 23:290-9.
7.Kim H., Kwon S., Jang Y., Nam M., Chung J., Na Y., Guo H. and Park O. (2013). GDSL LIPASE1 modulates plant immunity through feedback regulation of ethylene signaling. Plant Phys. 163:1776-91.
1.Wen X, Zhang C, Ji Y, Zhao Q, He W, An F, Jiang L, Guo H.* (2012). Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus. Cell Res. 22:1613-6.
2.Wang Q, Fristedt R, Yu X, Chen Z, Liu H, Lee Y, Guo H, Merchant SS, Lin C. (2012). The γ-carbonic anhydrase subcomplex of mitochondrial complex I is essential for development and important for photomorphogenesis of Arabidopsis. Plant Physiology 160:1373-83.
3.Zhong S., Shi H., Xue C., Wang L., Xi Y., Li J., Quail P.H., Deng X.*, and Guo H.* (2012). A Molecular Framework of Light-Controlled Phytohormone Action in Arabidopsis. Current Biology 22: 1530-35
4.Men Y., Yu Q., Chen Z., Wang J., Huang Y.* and Guo H.* (2012). A high-throughput imaging system to quantitatively analyze the growth dynamics of plant seedlings. Integrative Biology 4:945-52.
5.Shi Y., Tian S., Hou L., Huang X., Zhang X., Guo H. and Yang S. (2012). Ethylene signaling negatively regulates freezing tolerance by repressing expression of CBF and Type-A ARR genes in Arabidopsis. Plant Cell 24:2578-95.
6.Li Z, Peng J, Wen X, Guo H.* (2012). Gene Network Analysis and Functional Studies of Senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf Senescence. J Integr Plant Biol. 54:526-39.
7.An F., Zhu Z., Zhang X., Ji Y., He W., Jiang Z., Li M., and Guo H.* (2012). Coordinated regulation of apical hook development by gibberellin and ethylene in etiolated Arabidopsis seedlings. Cell Res. 22: 915-27.
1.He W., Brumos J., Li H., Ji Y., Ke M., Gong X., Zeng Q., Li W., Zhang X., An F., Wen X., Li P., Chu J., Sun X., Yan C., Yan N., Xie D., Raikhel N., Yang Z., Stepanova A.N., Alonso J.M. and Guo H.* (2011). A small-molecule screen identifies L-Kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis. Plant Cell 23:3944-60
2.Stepanova A.N., Yun J., Robles L.M., Novak O., He W., Guo H., Ljung K., Alonso J.M. (2011). The Arabidopsis YUCCA1 flavin monooxygenase functions in the Indole-3-Pyruvic Acid branch of auxin biosynthesis. Plant Cell 23:3961-73
3.Zhu Z., An F., Feng Y., Li P., Xue L., A M., Jiang Z., Kim J., To T., Li W., Yu Q., Dong Z., Chen W., Seki M., Zhou J. and Guo H.* (2011). Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis . Proc. Natl. Acad. Sci. USA. 108:12539-44.
4.Zhao Q. and Guo H.* (2011). Paradigms and paradox in the ethylene signaling pathway and interaction network. Mol. Plant 4:626-34
5.Li H., Lin D., Dhonukshe P., Nagawa S., Chen D., Friml J., Scheres B., Guo H., Yang Z. (2011). Phosphorylation switch modulates the interdigitated pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis. Cell Res. 21:970-8
6.Jiang Z, Liu X, Peng Z, Wan Y, Ji Y, He W, Wan W, Luo J,* Guo H.* (2011). AHD2.0: an update version of Arabidopsis Hormone Database for plant systematic studies. Nucleic Acids Research 39: D1123-9. ( *Co-Corresponding Author)
7.Liu X., Li Z. Jiang Z., ZhaoY., Peng J., Jin J., Guo H*., Luo J.* (2011). LSD: a leaf senescence database. Nucleic Acids Research 39: D1103-7. ( *Co-Corresponding Author)
1. An F., Zhao Q., Ji Y., Jiang Z., Yu X., Liu Y., Han Y., Zhang C., Zhang S., Ecker J.R., and Guo H.* (2010). Ethylene-Induced Stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 Is Mediated by Proteasomal Degradation of EIN3 Binding F-Box 1 and 2 That Requires EIN2 in Arabidopsis . Plant Cell 22:2384-401
2.Jiang Z. and Guo H.* (2010). A comparative genomic analysis of plant hormone related genes in different species. J. Genet. Genomics 37:219-30
3.Zhong S., Shi H., Xi Y. and Guo H.* (2010). Ethylene is crucial for cotyledon greening and seedling survival during de-etiolation. Plant Signaling & Behavior 5: 739-42
1.Zhong S., Zhao M., Shi T., Shi H., An F., Zhao Q. and Guo H.* (2009). EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and to promote greening of Arabidopsis seedlings. Proc. Natl. Acad. Sci. USA. 106: 21431-36.
2.Peng Z., Zhou X., Li L., Yu X., Li H., Jiang Z., Cao G., Bai M., Wang X., Jiang C., Lu H., Hou X., Qu L.,Wang Z., Zuo J., Fu X., Su Z., Li S., and Guo H.* (2009). Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis. Nucleic Acids Research 37: 975-82.
3.Chen H., Xue L., Chintamanani S., Germain H., Lin H., Cui H., Cai R., Zuo J., Tang X., Li X., Guo H., and Zhou J. (2009). ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis. Plant Cell 21:2527-40.
4.Li H., Wong W., Zhu L., Guo H., Ecker J.R., and Li N. (2009). Phosphoproteomic analysis of ethylene-regulated protein phosphorylation in etiolated seedlings of Arabidopsis mutant ein2 using two-dimensional separations coupled with a hybrid quadruple time-of-flight mass spectrometer. Proteomics 9:1646-61.
1. Zhu Z. and Guo H.* (2008). Genetic basis of ethylene perception and signal transduction in Arabidopsis. Journal of Integrative Plant Biology 50: 808-15.
1. Li H. and Guo H.* (2007). Molecular basis of the ethylene signaling and response pathway in Arabidopsis. Journal of Plant Growth Regulation 26: 106-17.
1.Olmedo G., Guo H., Gregory B., Nourizadeh S., Aguilar-Henonin L., Li H., An F., Guzman P., and Ecker J.R. (2006). ETHYLENE-INSENSITIVE5 encodes a 5’→3′ exoribonuclease required for posttranscriptional regulation of the EIN3-targeting F-box proteins EBF1/2. Proc. Natl. Acad. Sci. USA. 103: 13286-93 (* co-first author).
2.An F., and Guo H.* (2006) The Molecular Mechanism of Ethylene Signal Transduction.Chinese Botany Bulletin 23: 531-42.
Before 2005: 1.Guo H. and Ecker J.R. (2004). The ethylene signaling pathway: new insights. Curr Opin Plant Biol. 7: 40-9.
2.Guo H. and Ecker J.R. (2003). Plant responses to ethylene gas are mediated by SCFEBF1/EBF2-dependent proteolysis of EIN3 transcription factor. Cell 115: 667-77.
3.Shalitin D., Yang H., Mockler T., Maymon M., Guo H., Whitelam G., and Lin C. (2002). Regulation of Arabidopsis cryptochrome 2 by blue light-dependent phosphorylation. Nature 417: 763-7.
4.Guo H., Mockler T., Duong H., and Lin C. (2001). SUB1, an Arabidopsis Ca2+-binding protein involved in cryptochrome and phytochrome coaction. Science 291: 487-90.
5.Guo H., Duong H., Ma N., and Lin C. (1999). The Arabidopsis blue light receptor cryptochrome 2 is a nuclear protein regulated by a blue light-dependent post-transcriptional mechanism. Plant J. 19: 279-87.
6.Mockler T., Guo H., Yang H., Duong H., and Lin C. (1999). Antagonistic actions of the Arabidopsis cryptochromes and phytochrome B in the regulation of floral induction. Development 126: 2073-82.
7.Guo H., Yang H., Mockler T., and Lin C. (1998). Regulation of flowering time by Arabidopsis photoreceptors. Science 279: 1360-3.
8.Lin C., Yang H., Guo H., Mockler T., Chen T., and Cashmore A.R. (1998). Enhancement of blue-light sensitivity of Arabidopsis seedling by a blue light receptor cryptochrome 2. Proc. Natl. Acad. Sci. USA 95: 2686-90.