Dr. Liu studied clinical medicine at Nan Chang University and then was trained in biochemistry and molecular biology at Peking University Health Science Center. He joined in Hongwei Wang’s group as a postdoc at Tsinghua University. Dr. Liu published several research papers in top journals including Cell, Nature Chemical Biology, etc.
We use the Cryo-EM, biochemistry, molecular biology and cell biology to study the mechanism of macromolecular complexes. Our research interests include: 1) Studies on the mechanism underlying ribonucleic protein complexes. 2) Studies on the mechanism underlying G protein coupled receptors.
◆ 2019-Present: assistant professor, Department of Biology, SUSTech, Shenzhen.
◆ 2015-2019: Postdoctoral Fellow, School of Life Sciences, Tsinghua University.
◆ 2009-2015 Ph.D. Department of Biochemistry and Molecular Biology, Peking University Health Sciences Center.
◆ 2004-2009 Bachelor degree of medicine, School of Medicine, Nan Chang University
◆Yuan, D.#,Liu, Z.#, Kaindl, J.#, Maeda, S., Zhao, J., Sun X., Xu, J., Gmeiner, P., Wang HW., Kobilka, BK. (2019). Activation of the a2B adrenergic receptor by the sedative sympatholytic dexmedetomidine. Nature Chemical Biology.(# co-first authors, accepted)
◆Liu, Z.#, Wang, J.#, Cheng, H.#, Ke, X.#, Sun, L., Zhang, Q.C., and Wang, H.W. (2018). Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell 173, 1191-1203 e1112(# co-first authors).
◆Guan, Z., Cai, T., Liu, Z., Dou, Y., Hu, X., Zhang, P., Sun, X., Li, H., Kuang, Y., Zhai, Q., et al. (2017). Origin of the Reflectin Gene and Hierarchical Assembly of Its Protein. Curr Biol 27, 2833-2842 e2836.
◆Qin, S., Yin, H., Yang, C., Dou, Y., Liu, Z., Zhang, P., Yu, H., Huang, Y., Feng, J., Hao, J., et al. (2016). A magnetic protein biocompass. Nat Mater 15, 217-226.
◆Liu, Z., Wang, J., Li, G., and Wang, H.W. (2015). Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain. Protein Cell 6, 185-193.
◆Li, C., Wang, S., Jiang, W., Li, H., Liu, Z., Zhang, C., McNutt, M.A., and Li, G. (2012). Impact of intracellular alpha fetoprotein on retinoic acid receptors-mediated expression of GADD153 in human hepatoma cell lines. Int J Cancer 130, 754-764.
◆Wang, S., Jiang, W., Chen, X., Zhang, C., Li, H., Hou, W., Liu, Z., McNutt, M.A., Lu, F., and Li, G. (2012). Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma. J Hepatol 57, 322-329.