YAO Mingxi
Assistant Professor


      Yao Mingxi is currently a tenure-track assistant professor in the BME department, SUSTech. His research interests lie in the molecular mechanisms of mechanosensing in health and disease, utilizing diverse techniques such as single molecule manipulation, nano fabrication and advanced bioimaging. Dr Yao has studied the working principle of several important mechanosensing proteins and uncovered novel force-dependent crosstalk between mechanosensitive ion channels and focal adhesions that relates to neoplastic transformation.



2009-2014 National University of Singapore  PhD in Mechanobiology (Supervisor: Dr Jie Yan)

2005-2009 National University of Singapore  Bachelor of Science (Honors) in Computational Biology


Work Experience:

2021-至今  Department of Biomedical Engineering, SUSTech  Assistant Professor

2016-2021  Mechanobiology Institute, NUS Research Fellow (Supervisor: Dr Michael Sheetz)

2015-2016  Mechanobiology Institute, NUS  Research Associate



2014  Chinese Government Award for Outstanding Self-financed Students Abroad

2010   Merlion PhD Scholarship

2003   Singapore Government SM2 Undergraduate Scholarship


Selected Papers:

(1) Yao, Mingxi#; Qiu, Wu#; Liu, Ruchuan; Efremov, Artem K; Cong, Peiwen; Seddiki, Rima; Payre, Manon; Lim, Chwee Teck; Ladoux, Benoit; Mège, René-Marc*; Yan, Jie*; Force-dependent conformational switch of α-catenin controls vinculin binding , Nature Communications, 2014, 5(4525).

(2) Yao, Mingxi#; Goult, Benjamin T#; Klapholz, Benjamin; Hu, Xian; Toseland, Christopher P; Guo, Yingjian; Cong, Peiwen; Sheetz, Michael P*; Yan, Jie*; The mechanical response of talin., Nature Communications, 2016, 7(1): 0-11966.

(3) Yao, Mingxi#; Goult, Benjamin T#; Chen, Hu; Cong, Peiwen; Sheetz, Michael P*; Yan, Jie*; Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation, Scientific Reports, 2014, 4(4610).

(4) Le, Shimin#; Yao, Mingxi#; Chen, Jin; Efremov, Artem K; Azimi, Sara; Yan, Jie*; Disturbance-free rapid solution exchange for magnetic tweezers single-molecule studies, Nucleic Acids Research, 2015, 43(17): e113.

(5) Yao, Mingxi; Chen, Hu; Yan, Jie*; Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures, Integrative Biology, 2015, 7(10): 1154-1160.