Faculty

Bo XIAO
Professor
xiaob@sustech.edu.cn

Self-introduction
An immunologist turned neurobiologist, Dr. Xiao was trained in immunology first at Beijing Medical University and then at the University of Toronto, Canada. He joined the Johns Hopkins University School of Medicine, Baltimore, to study neuroscience, first as postdoctoral fellow and then as a research faculty. Dr. Xiao is among the 20 most cited Chinese neuroscientists (2014-2018) in the mainland China.

 

Research Interests:
◆ Functional Interactions Among Neurons and Neuroglia in Health and Disease;
◆ Molecular Regulation of Oligodendrocyte and Myelin development;
◆ Microglia Function in Neuro-Degeneration/Regeneration;
◆ Neuro-Metabolism, Oxidative Stress, and Neuro-Degeneration.

 

Professional Experience:
◆ 2017—Present: Professor, Department of Biology, SUSTech, Shenzhen;
◆ 2015—2018: Professor, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu;
◆ 2001—2005: Research Faculty, Johns Hopkins University School of Medicine, Baltimore;
◆1997—2001: Postdoctoral Fellow, Department of Neuroscience, Johns Hopkins University, Baltimore;
◆ 1993—1997: Postdoctoral Fellow, Department of Immunology, University of Toronto, Toronto;

 

Educational Background:
◆ 1979—1984: Undergraduate Studies, School of Medicine, West China University of Medical Sciences;
◆1986—1989: Graduate Studies (Msc), Department of Immunology, West China University of Medical Sciences;
◆ 1990—1993: Graduate Studies (Ph.D.), Department of Immunology, Beijing Medical University;

 

Selected Publication:
1.Yang W, Pang D, Du C, Jiang W, Luo L, Yu Z, Tang P, Xia X, Cui Y, Chen C, Liu Y, Wei Y-Q, Worley P.F, Xiao B*. Rheb1 controls mitochondrial energy metabolism by activating pyruvate dehydrogenase independently of mTORC1. Nature Communications, 2019, submitted

2. Tan H, Chen M, Xia X, Pang D, Du C, Yang W, Cui Y, Huang C, Jiang W, Li C, Shang H, Worley PF, Xiao B*. LanCL1 Promotes Motor Neuron Survival and Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice. Cell Death and Differentiation, 2019, submitted

3.Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017; 7;114(10):E1996-E2005.

4.Ahuja M, Schwartz DM, Tandon M, Son A, Zeng M, Swaim W, Eckhaus M, Hoffman V, Cui Y, Xiao B, Worley PF, Muallem S Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity. Cell Metabolism. 2017 Mar 7;25(3):635-646.

5.Eunchai Kang, Ju Young Kim, Cindy Y Liu, Bo Xiao, Po Yu Chen, Kimberly M Christian, Paul F Worley, Hongjun Song, Guo-li Ming Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus. Neurogenesis 2015; 2(1)

6.Zou Y, Jiang W, Zhang J, Bu J, Wang J, Zou J, Zhou L, Yu S, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B*. Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. Journal of Neuroscience. 2014, 34(47):15764-15778
7.Huang C, Chen M, Pang D, Bi D, Zou Y, Xia X, Yang W, Luo L, Deng R, Tan H, Zhou L, Yu S, Guo L, Du X, Cui Y, Hu J, Mao Q, Worley PF, Xiao B*. Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Developmental Cell. 2014;30(4): 479-487 (Featured Article)

8.Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PU, Worley PF, Bo Xiao*. Rheb1 is Required for mTORC1 and Myelination in Postnatal Brain Development. Developmental Cell. 2011;20(1):97-108

9.Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience, 2013; 16(2):174-82

10.Cao Y, Tao L, Shen S, Xiao J, Wu H, Li B, Wu X, Luo W, Xiao Q, Hu X, Liu H, Nie J, Lu S, Yuan B, Han Z, Xiao B, Yang Z, Li X. Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice. Int J Mol Sci. 2013;14(12):24380-98.

11.Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell 2013;154(3):637-50

12.Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, and Powell CM. Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission. Journal of Neuroscience 2013, 33(47): 18448-18468

13.Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK. Homers at the Interface between Reward and Pain. Front Psychiatry. 2013; 7;4:39

14. Hu JH,Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I Metabotropic glutamate receptors. Nature Neuroscience, 2012;15(6),836-844

15.Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nature Immunology. 2011; 12(4):295-303

16.Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of LTD in cultured cerebellar Purkinje cells. Nature Neuroscience. 2010;13(9): 1082-1089

17.Hu JH, Park JM, Park S, Xiao B, Dehoff MD, Kim S, Hayashi T, Schwarz M, Huganir RL, Seeburg PH, Linden DJ, Worley PF. Homeostatic Scaling requires Group I mGluR activation mediated by Homer1a Neuron. 2010;68(6):1128-1142

18.Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30(6):832-844

19.Ango F, Prezeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature. 2001;411(6840):962-965

20.Xiao B, Tu JC, Worley PF. Homer: a link between neural activity and glutamate receptor function (invited). Curr Opin Neurobiol. 2000;10(3):370-374

21.Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Lanahan AA, Wenthold RJ, Worley PF. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21(4):707-716

22.Tu JC, Xiao B (co-first author), Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Lanahan AA, Sheng M, Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron.1999;23(3):583-592

23.Tu JC, Xiao B (co-first author), Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21(4):717-726

24.Beneken J, Tu JC, Xiao B, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 2000;26(1):143-154