师资

陈浩
助理教授
chenh7@sustech.edu.cn

个人简介:

陈浩,南方科技大学医学院助理教授、博士生导师。近年来,主导和参与了表观遗传学修饰异常与代谢紊乱、信号传导通路调控表观遗传学修饰等一系列研究工作,并且鉴定了多种全新的表观遗传学修饰模式及详细阐明其在各类疾病发生中的分子机制。相关研究成果已发表于Nature, Science, Cell, Cell Research, PNAS等业内著名期刊,发表研究论文共16篇(平均影响因子17.06),其中第一作者研究论文8篇,高引用论文3篇。

 

教育背景:

2004.09-2008.06 武汉大学  生物学基地班  学士

2008.09-2013.06 复旦大学 生物医学研究院 博士

 

工作经历:

2013.07-2014.11  复旦大学   基础医学院   助理研究员

2015.02-2019.12  哈佛大学  波士顿儿童医院  博士后

 

获奖情况及荣誉:

2013      优秀毕业生           复旦大学

2013      最佳汇报奖           肿瘤生物学转化医学论坛

2012      国家奖学金           中国教育部

2012      最佳汇报奖           上海生命科学论坛

 

研究领域:

  1. 疾病发生的表观遗传学机制;
  2. 新型表观遗传学修饰的鉴定与功能研究。

 

发表论文:

First/Co-first author

1.Chen, H., Shi, Z., Guo, J., Chang, K., Chen, Q., Yao, C., Haigis,M., Shi, Y. (2020). The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function. Journal of Biological Chemistry. RA119. 012127

2.Chen, H.#, Gu, L.#, Orellana, E., Wang, Y., Guo, J., Liu, Q., Gregory, R., Xing, Y., Shi, Y. (2020). METTL4 is an m6Am methyltransferase that regulates RNA splicing. Cell Research. doi:1038 /s41422-019-0270-4 (#co-first author) (F1000 recommended)  

3.Chen, H., Yu, D., Fang, R., Rabidou, K., Wu, D., Hu, D., . . Shi, Y. G. (2019). TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer. Cell Research. 29, 248–250.

4.Wu, D.#, Hu, D.#, Chen, H.#, Shi, G.#, Fetahu, I. S., Wu, F., . . . Shi, Y. G. (2018). Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 559(7715), 637-641. (#co-first author) (Highlighted by Nature Reviews Cancer, Nature Reviews Molecular Cell Biology, Science, Trends in Cancer, Cancer Discovery and Cell Metabolism)

5.Chen, H., Ma, H., Inuzuka, H., Diao, J., Lan, F., Shi, Y. G., . . . Shi, Y. (2013). DNA damage regulates UHRF1 stability via the SCFβ-TrCP E3 ligase. Molecular and Cellular Biology. 33: 1139-1148. (Spotlight in the issue)

6.Ma, H.#, Chen, H.#, Guo, X.#, Wang, Z., Sowa, M. E., Zheng, L., . . . Shi, Y. (2012). M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. PNAS (Proceedings of the National Academy of Sciences).109: 4828-4833. (#co-first author)

7.Gu, L.#, Wang, L.#, Chen, H.#, Hong, J.#, Shen, Z., Dhall, A., Lao, T., . . . Wu, H., Shi, Y. (2020). CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. bioRxiv. doi: https://doi.org/10.1101/2020.01.09.890764 (#co-first author)

8.Chen, H.#, Liu, Q.#, Yu, D., Natchiar, K., Zhou, C., Hsu, C.-h., Hsu, P.-H., Zhang, X., Klaholz, B., Gregory, R. and Shi, Y. (2020) METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes. bioRxiv. doi: https://doi.org/10.1101/2020.04.27.064162 (#co-first author)

Co-author

9.Sendinc, E., Valle-Garcia, D., Dhall, A., Chen, H., Henriques, T., Navarrete-Perea, J., Sheng, W., Gygi, S., Adelman, K., Shi, Y.(2019). PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Molecular Cell.

10.Lee, Y., Chen, M., Lee, J., Zhang, J., Lin, S., Fu, T., Chen, H., Ishikawa, T., Chiang, S.,  Katon, J.,  .... Wei W., Pandolfi P.(2019). Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 364,6441.  

11.Ma, H., Wang, X., Cai, J., Dai, Q., Natchiar, S. K., Lv, R., . . Chen, H., . . He,C. (2019). N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 15(1), 88.  

12.Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., . . Chen, H.,. . Shi, Y. (2018). LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell.174(3), 549-563 e519.

13.Xiang, Y., Laurent, B., Hsu, C.-H., Nachtergaele, S., Lu, Z., Sheng, W.,Chen, H., . . . Shi, Y.(2017). RNA m 6A methylation regulates the ultraviolet-induced DNA damage response. Nature. 543(7646), 573.   

14.Cai, J. B., Shi, G. M., Dong, Z. R., Ke, A. W., Ma, H. H., Gao, Q., Chen, H., . . Fan, J. (2015). Ubiquitin‐specific protease 7 accelerates p14ARF degradation by deubiquitinating thyroid hormone receptor‐interacting protein 12 and promotes hepatocellular carcinoma progression. Hepatology. 61(5), 1603-1614.

15.Guo, R., Zheng, L., Park, J. W., Lv, R.,Chen, H., Jiao, F., . Shi, Y. (2014). BS69/ZMYND11 reads and connects histone H3.3 lysine36 trimethylation-decorated chromatin to regulated pre-mRNA processing. Molecular Cell. 56(2), 298-310.

16.Rajakumara, E., Wang, Z., Ma, H., Hu, L., Chen, H., Lin, Y., Guo, R., Wu, F., Li, H., Lan, F., et al. (2011). PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Molecular Cell. 43, 275-284.  

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