师资

陈曦
助理教授
chenx9@sustech.edu.cn

个人简介:
2009 年毕业于北京大学医学部医学实验专业,取得学士学位,2012年在英国曼彻斯特大学生命科学系取得博士学位。博士期间以研究蛋白-DNA 结合特异性以及细胞周期 G2/M 期的调控为主题,发现并且阐明了一个促癌转录因子FOXM1调控G2/M期的特殊机制。在完成博士研究之后,于2013年来到欧洲生物信息研究所(European Bioinformatics Institute)从事博士后工作,进行表观遗传学、生物信息学,以及单细胞测序方面的研究。2016年加入维康桑格研究所(Wellcome Sanger Institute)成为高级研究员。2019年加入南方科技大学生物系,任助理教授。

 

研究领域:
(1) 单细胞表观遗传以及转录组测序技术开发
(2) 基因组学数据的挖掘以及生物信息分析
(3) 以T细胞和干细胞为模型,研究转录因子以及染色质复合物在控制细胞命运决定以及记忆中的作用和机制

 

工作经历:
2019 至 今 南方科技大学生物系 助理教授
2016 至 2019 维康桑格研究所 高级研究员
2013 至 2016 欧洲生物信息研究所 博士后
2012 至 2013 曼彻斯特大学生命科学系 研究助理

 

学习经历:
2009 至 2012 曼彻斯特大学生命科学系 博士
2005 至 2009 北京大学医学部医学实验专业 本科

 

代表文章: (*共同一作)
学术文章:

1. Henriksson, J.*, Chen, X.*, Gomes, T., Ullah, U., and Meyer, K.B. (2019). Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation. Cell 176, 1–15.

2.Zhang, W.*, Chronis, C.*, Chen, X.*, Zhang, H., Spalinskas, R., Pardo, M., Chen, L., Wu, G., Zhu, Z., Yu, Y., et al. (2019). The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell 24, 138–152.e8.

3.Chen, X., Miragaia, R.J., Natarajan, K.N., and Teichmann, S.A. (2018). A rapid and robust method for single cell chromatin accessibility profiling. Nat. Commun. 9, 5345.

4.Jia, G.*, Preussner, J.*, Chen, X.*, Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., et al. (2018). Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. Nat. Commun. 9, 4877.

5.Hagai, T., Chen, X., Miragaia, R.J., Rostom, R., Gomes, T., Kunowska, N., Henriksson, J., Park, J.-E., Proserpio, V., Donati, G., et al. (2018). Gene expression variability across cells and species shapes innate immunity. Nature 563, 197–202.

6.Pramanik, J., Chen, X., Kar, G., Henriksson, J., Gomes, T., Park, J.-E., Natarajan, K., Meyer, K.B., Miao, Z., McKenzie, A.N.J., et al. (2018). Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 10, 76.

7.Chen, X., Ji, Z., Webber, A., and Sharrocks, A.D. (2016). Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Res. 44, 1566–1578.

8.Yu, Y., Tsang, J.C.H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L.S., Lu, L., et al. (2016). Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 539, 102–106.

9.Aguilar-Martinez, E., Chen, X., Webber, A., Paul Mould, A., Seifert, A., Hay, R.T., and Sharrocks, A.D. (2015). Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin. Proc. Natl. Acad. Sci. U. S. A. 112, E4854–E4863.

10.Wiseman, E.F., Chen, X., Han, N., Webber, A., Ji, Z., Sharrocks, A.D., and Ang, Y.S. (2015). Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma. Mol. Cancer 14, 69.

11.Chen, X., Müller, G.A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A.D., and Engeland, K. (2013). The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol. Cell. Biol. 33, 227–236.

评论与综述:

1.Chen, X., Teichmann, S.A., and Meyer, K.B. (2018). From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture. Annu. Rev. Biomed. Data Sci. 1, 29-51.

2.Chen, X., Love, J.C., Navin, N.E., Pachter, L., Stubbington, M.J.T., Svensson, V., Sweedler, J.V., and Teichmann, S.A. (2016). Single-cell analysis at the threshold. Nat. Biotechnol. 34, 1111–1118.

3.Vieira Braga, F.A.*, Teichmann, S.A., and Chen, X.* (2016). Genetics and immunity in the era of single-cell genomics. Hum. Mol. Genet. 25, R141–R148.

图书章节:

1.Kunowska, N.*, Chen, X*. (2019). ChIPmentation for Low-Input Profiling of In Vivo Protein-DNA Interactions. Methods Mol Biol. 1979: 269-282.

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