师资

杜嘉木
教授
二零一六年科技部国家重点研发计划项目首席科学家 , 青年
dujm@sustech.edu.cn

个人简介:杜嘉木教授,基金委优秀青年科学基金获得者,科技部国家重点研发计划青年项目首席科学家;长期从事植物基因调控,特别是植物表观遗传调控相关的结构生物学和生物化学研究。揭示了植物花期调控受表观遗传因子调控的分子机理;阐释了植物DNA甲基化和组蛋白修饰相互调控的分子调控网络的作用机制。在Nature、Cell、Nature Genetics、Molecular Cell、Nature Communications、Plant Cell、PNAS等国际期刊上发表论文40余篇,授权国内专利2项。2014年9月回国任职中国科学院上海生命科学研究院植物逆境生物学研究中心研究员、博士生导师;2019年2月加入南方科技大学生物系植物与食品研究所,任职教授。

研究领域:
植物基因调控
植物表观遗传学
生物化学和结构生物学

工作经历:
2019/02–至今,教授,南方科技大学生物系植物与食品研究所
2017/10–2019/01,青年研究骨干,中国科学院分子植物卓越创新研究中心;植物分子遗传国家重点实验室
2014/09–2019/01,研究员,中国科学院上海生命科学研究院上海植物逆境生物学研究中心
2009/10–2014/08,博士后,纪念斯隆凯特琳癌症中心
2008/07–2009/09,助理研究员,中国科学院上海生命科学研究院上海生物化学与细胞生物学研究所

学习经历:
2003/09–2008/07,生物化学与分子生物学,博士,中国科学院上海生命科学研究院上海生物化学与细胞生物学研究所
1999/09–2003/07,生物学,学士,复旦大学

所获荣誉:
2018年,中国科学院优秀导师奖
2017年,国家自然科学基金委“优秀青年科学基金”
2016年,科技部国家重点研发计划项目首席科学家(青年)

代表文章:
(24) Zhang C#, Du X#, Tang K#, Yang Z, Pan L, Zhu P, Luo J, Jiang Y, Zhang H, Wan H, Wang X, Wu F, Tao WA, He XJ, Zhang H, Bressan RA, Du J*, Zhu JK*. Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin. Nat Commun. 2018b; 9: 4547. (* co-corresponding authors)
(23) Li X#, Harris CJ#, Zhong Z, Chen W, Liu R, Jia B, Wang Z, Li S, Jacobsen SE*, Du J*. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context biased non-CG DNA methylation. Proc Natl Acad Sci U S A. 2018; 115: E8793-E8802. (* co-corresponding authors)
(22) Yang Z#, Qian S#, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J*, Zhong X*. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat Genet. 2018; 50: 1247-1253. (* co-corresponding authors)
Highlighted by Nat Genet. 2018; 50: 1206–1208
(21) Qian S#, Lv X#, Scheid RN#, Lu L, Yang Z, Chen W, Liu R, Boersma MD, Denu JM, Zhong X*, Du J*. Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun. 2018; 9: 2425. (* co-corresponding authors)
(20) Yang Z, Qiu Q, Chen W, Jia B, Chen X, Hu H, He K, Deng X, Li S, Tao WA, Cao X*, Du J*. Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell. 2018; 30: 167-177. (* co-corresponding authors)
Highlighted by Plant Cell. 2018; 30: 5–6
(19) Liu R#, Li X#, Chen W, Du J*. Structure and mechanism of plant histone mark readers. Sci China Life Sci. 2018; 61: 170-177. Review Article.
(18) Du J*. Structure and Mechanism of Plant DNA Methyltransferases. Adv Exp Med Biol. 2016; 945: 173-92. Book Chapter.
(17) Li S, Yang Z, Du X, Liu R, Wilkinson AW, Gozani O, Jacobsen SE, Patel DJ, Du J*. Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Structure. 2016; 24: 486-94
(16) Du J#, Johnson LM#, Jacobsen SE, Patel DJ. DNA methylation pathways and their crosstalk with histone methylation. Nat Rev Mol Cell Biol. 2015; 1839: 519-32. (# co-first authors) Review Article
(15) Du J*, Patel DJ*. Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (Gene Regulatory Mechanisms). 2014; 1839:719-27. (* co-corresponding authors) Review Article
(14) Du J#, Johnson LM#, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol Cell. 2014; 55, 495–504. (# co-first authors)
(13) Zhong X#, Du J#, Hale CJ, Gallego-Bartolome J, Feng S, Vashisht AA, Chory J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell. 2014; 157: 1050-60. (# co-first authors)
(12) Johnson LM#, Du J#, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014; 507: 124-8. (# co-first authors)
(11) Law JA#, Du J#, Hale CJ#, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE. Polymerase-IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 2013; 498: 385-89. (# co-first authors)
(10) Du J#, Zhong X#, Bernatavichute YV, Stroud H, Feng S, Caro E, Vashisht AA, Terragni J, Chin HG, Tu A, Hetzel J, Wohlschlegel JA, Pradhan S, Patel DJ, Jacobsen SE. Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell. 2012; 151:167-80. (# co-first authors)
(9) Du J, Kelly AE, Funabiki H, Patel DJ. Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure. 2012 ;20:185-95.
(8) Du J, Yang H, Zhang D, Wang J, Guo H, Peng B, Guo Y, Ding J. Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab. J Immunol. 2010; 184:1361-8.
(7) Du J#, Yang H#, Peng B, Ding J. Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of beta-2-microglobulin by antibody BBM.1. J Mol Recognit. 2009; 22:465-73. (# co-first authors)
(6) Du J, Yang H, Guo Y, Ding J. Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. Mol Immunol. 2009; 46:2419-23.
(5) Du J#, Hou S#, Zhong C#, Lai Z, Yang H, Dai J, Zhang D, Wang H, Guo Y, Ding J. Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis. J Mol Biol. 2008; 382:835-842. (# co-first authors)
(4) Yu XL#, Hu T#, Du JM#, Ding JP#, Yang XM, Zhang J, Yang B, Shen X, Zhang Z, Zhong WD, Wen N, Jiang H, Zhu P, Chen ZN. Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem. 2008; 283:18056-65. (# co-first authors)
(3) Du J#, Wang H#, Zhong C, Peng B, Zhang M, Li B, Hou S, Guo Y, Ding J. Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide. Mol Immunol. 2008; 45:2861-8. (# co-first authors)
(2) Du J, Wang H, Zhong C, Peng B, Zhang M, Li B, Hou S, Guo Y, Ding J. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J Biol Chem. 2007; 282:15073-80.
(1) Zhang P#, Du J#, Sun B, Dong X, Xu G, Zhou J, Huang Q, Liu Q, Hao Q, Ding J. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res. 2006; 34:6621-8. (# co-first authors)

联系方式:
深圳市南山区西丽学苑大道1088号南方科技大学B栋208室
邮编:518055
电子邮件:dujm@sustech.edu.cn
Professor——Jiamu Du

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