个人简介：秦超博士，南方科技大学医学院生物化学系助理教授、独立PI、博士生导师。2019年博士毕业于中国农业大学，同年赴美国南加州大学从事博士后研究，并于2024年晋升为Research Assistant Professor。2026年5月加入南方科技大学医学院。长期致力于细胞代谢、病毒感染和肿瘤发生发展的交叉研究，相关研究成果以第一作者身份（含共一）发表于Immunity、Molecular Cell、PNAS、PLOS Pathogens和mBio等国际权威期刊。

教育背景：

2014-09至2019-06, 中国农业大学，博士

2010-09至2014-07, 山东农业大学，学士

工作经历：

2026-05至今，南方科技大学医学院，助理教授（Assistant Professor）

2024-06至2026-02，美国南加州大学，研究助理教授（Research Assistant Professor）

2022-07至2024-05，美国南加州大学，Research Associate

2019-08至2022-06，美国南加州大学，博士后

获奖情况及荣誉：

2023年 南加州大学口腔医学院Post-doctoral Trainee Award

2025年 南加州大学口腔医学院Faculty Outstanding Service Award

研究领域：

依托LC-MS技术开展代谢组学和蛋白质组学分析，并结合分子病毒学、细胞生物学和免疫学等研究手段，开展前沿交叉研究。主要研究方向包括：（1）细胞代谢与病毒感染及抗病毒免疫的交叉作用，重点关注代谢酶和代谢物在病毒复制与天然免疫调控中的非经典功能;（2）细胞代谢酶活性的调控机制及其在病毒感染和肿瘤发生发展中的作用。

发表论文：

Lead-authorship Publications

1. Qin C, An Z, Feng S, Fu W, Xie X, Savas AC, Xie T, Brenner C, Saito T, Feng P. Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation. Molecular Cell. 2026. 86, 1-17. https://doi.org/10.1016/j.molcel.2026.03.016

2. Rao Y*, Qin C*, Savas AC, Liu Q, Feng S, Hou G, Xie T, Feng P. Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3. Immunity. 2025 Jan 14;58(1):74-89.e6. doi: 10.1016/j.immuni.2024.11.020. (*co-first author)

3. Rao Y*, Qin C*, Espinosa B, Wang T, Feng S, Savas AC, Jill H, Comai L, Zhang C, Feng P. Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection. mBio. 2025 Jun 11;16(6):e0064925. (*co-first author)

4. Qin C*, Xie T, Yeh WW, Savas AC, Feng P*. Metabolic Enzymes in Viral Infection and Host Innate Immunity. Viruses. 2024, 16(1), 35. (*co-corresponding author)

5. Qin C, Feng S, Feng P. STeerING PI4P for innate immune activation. Immunity. 2023, 14;56(3):463-465.

6. Qin C, Rao Y, Yuan H, Wang T, Zhao J, Espinosa B, Liu Y, Zhang S, Savas AC, Liu Q, Zarinfar M, Rice S, Henley J, Comai L, Graham NA, Chen C, Zhang C, Feng P. SARS-CoV-2 Couples Evasion of Inflammatory Response to Activated Nucleotide Synthesis. Proceedings of the National Academy of Sciences (PNAS). 2022, 119(26):e2122897119

7. Qin C, Zhang R, Lang Y, Shao A, Xu A, Feng W, Han J, Wang M, He W, Yu C, Tang J.  Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3. PLOS Pathogens. 2019, 15, e1007559.

Co-authorship Publications

8. Feng S, Xie N, Liu Y, Qin C, Savas AC, Wang TY, Li S, Rao Y, Shambayate A, Chou TF, Brenner C, Huang C, Feng P. Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins. Nature Metabolism. 2024 Dec;6(12):2300-2318. doi: 10.1038/s42255-024-01162-0.

9. Xie T, Qin C, Savas AC, Yeh WW, Feng P. The emerging roles of glutamine amidotransferases in metabolism and immune defense. Nucleosides Nucleotides Nucleic Acids. 2024;43(8):783-797. doi: 10.1080/15257770.2024.2351135.

10. Gao C, Xiao C, Wang M, Liang X, Qin C, Zhang H, Bai R, Zhang R, Feng W, Yang J, Tang J. HIF-1 Transcriptionally Regulates Basal Expression of STING to Maintain Cellular Innate Immunity. Journal of Immunology. 2024 Aug 15;213(4):494-505. doi: 10.4049/jimmunol.2400123.

11. Cui Q, Jeyachandran AV, Garcia G, Qin C, Zhou Y, Zhang M, Wang C, Sun G, Liu W, Zhou T, Feng L, Palmer C, Li Z, Aziz A, Gomperts BN, Feng P, Arumugaswami V, Shi Y. The Apolipoprotein E neutralizing antibody inhibits SARS-CoV-2 infection by blocking cellular entry of lipoviral particles. MedComm. 2023, 4(5):e400

12. Zhang X, Meng W, Feng J, Gao X, Qin C, Feng P, Huang Y, Gao SJ. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Cell Death and Disease. 2023, 14(9):591

13. Ngo C, Fried W, Aliyari S, Feng J, Qin C, Zhang S, Yang H, Shanaa J, Feng P, Cheng G, Chen XS, Zhang C. Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. Journal of Medicinal Chemistry. 2023, 66(17):12237-12248

14. Dong W, Wang J, Tian L, Zhang J, Settles E, Qin C, et al. Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection. Nature Communications. 2023, 14, 1936.

15. Wang M, Song J, Gao C, Yu C, Qin C, Lang Y, Xu A, Liu Y, Feng W, Tang J, Zhang R. UHRF1 Deficiency Inhibits Alphaherpesvirus through Inducing RIG-I-IRF3-Mediated Interferon Production. Journal of Virology. 2023, 97(3):e0013423

16. Kim K, Calabrese P, Wang S, Qin C, Rao Y, Feng P, Chen XS. The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness. Scientific Reports. 2022 Sep 13;12(1):14972. doi: 10.1038/s41598-022-19067-x.

17. Wang M, Liu Y, Qin C, Lang Y, Xu A, Yu C, Zhao Z, Zhang R, Yang J, Tang J. Pseudorabies Virus EP0 Antagonizes the Type I Interferon Response via Inhibiting IRF9 Transcription. Journal of Virology. 2022, 13;96(13):e0217121

18. Wang C, Qu R, Zong Y, Qin C, Liu L, Gao X, Sun H, Sun Y, Chang KC, Zhang R, Liu J, Pu J. Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals. PLOS Pathogens. 2022, 18(7):e1010645

19. Zhang R, Xue T, Shao A, Lang Y, Qin C, Zhao M, Kuang Y, Yu Z, Geng Y, Zhao C, Tang J. Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury. EMBO Report. 2022, 23:e52702

20. Liu Y, Qin C, Rao Y, Ngo C, Feng JJ, Zhao J, Zhang S, Wang TY, Carriere J, Savas AC, Zarinfar M, Rice S, Yang H, Yuan W, Camarero JA, Yu J, Chen XS, Zhang C, Feng P. SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. mBio. 2021, 12(5):e0233521

21. Zhang R, Chen S, Zhang Y, Wang M, Qin C, Yu C, Zhang Y, Li Y, Chen L, Zhang X, Yuan X, Tang J. Pseudorabies Virus DNA Polymerase Processivity Factor UL42 Inhibits Type I Interferon Response by Preventing ISGF3-ISRE Interaction. Journal of Immunology. 2021, 207 (2) 613-625.

22. Huang H, Zhao J, Wang TY, Zhang S, Zhou Y, Rao Y, Qin C, Liu Y, Chen Y, Xia Z, Feng P. Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication. mBio. 2021 Mar 30;12(2):e00115-21. doi: 10.1128/mBio.00115-21.

23. Zhao J, Qin C, Liu Y, Rao Y, Feng P. Herpes Simplex Virus and Pattern Recognition Receptors: An Arms Race. Frontiers in Immunology. 2021, 11:613799

24. Yu C, Xu A, Lang Y, Qin C, Yuan X, Feng W, Wang M, Gao C, Chen J, Zhang R, Tang J. Swine Promyelocytic Leukemia Isoform II Inhibits Pseudorabies Virus Infection by Suppressing Viral Gene Transcription in PML-NBs. Journal of Virology. 2020, 94(18):e01197-20.

25. Shao A, Lang Y, Wang M, Qin C, Kuang Y, Mei Y, Lin D, Zhang S, Tang J. Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia. Oncogene. 2020, 29:2807-2818.

26. Zhang R, Xu A, Qin C, Zhang Q, Chen S, Lang Y, Wang M, Li C, Feng W, Zhang R, Jiang Z, Tang J. Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response. Journal of Virology. 2017, 91(21):e01148-17.

27. Xu A, Qin C, Lang Y, Wang M, Lin M, Li C, Zhang R, Tang J. A simple and rapid approach to manipulate pseudorabies virus genome by CRISPR/Cas9 system. Biotechnology Letters. 2015 Jun;37(6):1265-72. doi: 10.1007/s10529-015-1796-2.