师资

田瑞军
教授
0755-88018905
tianrj@sustech.edu.cn

田瑞军,南方科技大学化学系教授(研究员),博士生导师(香港浸会大学-南方科技大学联合博士培养项目),加拿大渥太华大学医学院兼职教授,中国蛋白质组组织CNHUPO常务理事。

 

2008年在中国科学院大连化学物理研究所获得分析化学博士学位,师从邹汉法研究员,并获得中国科学院院长优秀奖和中国科学院优秀毕业生奖励。同年加入加拿大渥太华系统生物学研究所进行博士后研究,师从Daniel Figeys教授。2010年加入加拿大多伦多大学和西奈山医院继续博士后研究,师从Tony Pawson院士,并获得加拿大国立卫生研究院(CIHR)博士后基金资助。2014年起受聘南方科技大学化学系副教授(研究员),教授。致力于蛋白质组学的方法学和应用研究,在细胞信号转导、肿瘤微环境和干细胞定向分化等生物医学方向开展了卓有成效的应用研究。已在国际主流学术期刊上发表论文近40篇,其中以责任作者在PNAS、Mol. Cell. Proteomics、Anal. Chem.、Angew Chem.等上发表文章近20篇,SCI他1000余次,H-index为20。曾荣获深圳市海外高层次人才“孔雀计划” B类人才(2014)、由国际蛋白质结构分析和蛋白质组学协会(IAPSAP)颁发的2012 Young Investigator Award,并在第八届世界蛋白质组学大会(HUPO)等做邀请或口头报告40余次。曾担任第二届中国蛋白质组组织(CNHUPO)第二届青年学者研讨会执行主席。目前担任Scientific Reports (Nature Publishing Group)、Frontiers in Endocrinology和Austin Proteomics三种国际期刊的编委会委员职务。

 

代表性论文 (h-index = 25, Google scholar)

Corresponding-author and first-author papers:

  1. Yu Shi, Weina Gao, Nikki K. Lytle, Peiwu Huang, Xiao Yuan, Amanda M. Dann, Maya Ridinger, Kathleen E. DelGiorno, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Puifai Santisakultarm, Uri Manor, Ruilian Xu, Mathias Leblanc, Sarah E. Umetsu, Eric A. Collisson, Andrew M. Lowy, Tannishtha Reya, Timothy R. Donahue, Michael Downes, Geoffrey M. Wahl, Ronald M. Evans, Tony Pawson, Ruijun Tian, Tony Hunter, Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring, Nature, accepted
  2. Mi Ke*, Jie Liu*, Wendong Chen, Lan Chen, Weina Gao, Yunqiu Qin, An He, Bizhu Chu, Jun Tang, Ruilian Xu, Yi Deng, Ruijun Tian, An integrated and quantitative proteomic approach for charting temporal and endogenous protein complexes. Anal. Chem. 2018, 90, 12574-12583
  3. Bizhu Chu*, An He*, Yeteng Tian, Wan He, Peizhong Chen, Jintao Hu, Ruilian Xu, Wenbin Zhou, Mingjie Zhang, Pengyuan Yang, Shawn S. C. Li, Ying Sun, Pengfei Li, Tony Hunter, Ruijun Tian. Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. PNAS, 2018, 115, E8863-E8872
  4. Ruilian Xu*, Jun Tang*, Quantong Deng, Wan He, Xiujie Sun, Ligang Xia, Zhiqiang Cheng, Lisheng He, Shuyuan You, Jintao Hu, Yuxiang Fu, Jian Zhu, Yixin Chen, Weina Gao, An He, Zhengyu Guo, Lin Lin, Hua Li, Chaofeng Hu, and Ruijun Tian, Spatial-Resolution Cell Type Proteome Profiling of Cancer Tissue by Fully Integrated Proteomics Technology, Anal. Chem. 2018, 90, 5879−5886
  5. Lin Lin, Jiaxin Zheng, Quan Yu, Wendong Chen, Jinchun Xing, Chenxi Chen, Ruijun Tian, High throughput and accurate serum proteome profiling by integrated sample preparation technology and single-run data independent mass spectrometry analysis, J. Proteomics, 2018, 174, 9-16
  6. Wendong Chen, Lan Chen, Ruijun Tian, Integrated strategy for high-sensitive phosphoproteome analysis from low micrograms of protein samples, Analyst, 143, 3693-3701
  7. Xue Lu*, Lin Lin*, Wenbin Zhou, Wendong Chen, Jun Tang, Xiujie Sun, Peiwu Huang, Ruijun Tian, Mixed-mode ion exchange-based integrated proteomics technology for fast and deep plasma proteome profiling, J. Chromatogr. A, 2018, 1564, 76-84
  8. Adhikari Subash, Lan Chen, Peiwu Huang, Ruijun Tian, Proteomic Analysis of Secreted Proteins from Cell Microenvironment, Methods Mol. Biol., 2017, 1662, 45-58
  9. Xu Zhang*, Wendong Chen*, Zhibin Ning, Janice Mayne, David R. Mack, Alain Stintzi‡, Ruijun Tian‡, Ruijun Tian, and Daniel Figeys, Deep Metaproteomics Approach for the Study of Human Microbiomes, Anal. Chem., 2017, 89, 9407-9415
  10. Wendong Chen, Subash Adhikari, Lan Chen, Lin Lin, Hua Li, Shusheng Luo, Pengyuan Yang, Ruijun Tian, 3D-SISPROT: A simple and integrated spintip-based protein digestion and three-dimensional peptide fractionation technology for deep proteome profiling, J. Chromatogr. A, 2017, 1498, 207-214
  11. Mi Ke, Bizhu Chu, Lin Lin, Ruijun Tian, SH2 Domains as Affinity Reagents for Phosphotyrosine Protein Enrichment and Proteomic Analysis, Methods Mol. Biol., 2017, 1555, 395-406 (Book chapter)
  12. Jun Tang, Kaizhu Guo, Wendong Chen, Peipei Song, Shun Feng, Chaofeng Hu, Ruilian Xu, Ruijun Tian, A Fe3O4/EDTA Magnetic Beads-Based Integrated Method for Proteomic Analysis, Chinese J. Chromatogr., 2016, 34, 1263-1269
  13. Mi Ke, Hainan Shen, Linjue Wang, Shusheng Luo, Lin Lin, Jie Yang, Ruijun Tian, Identification, Quantification, and Site Localization of Protein Posttranslational Modifications via Mass Spectrometry-Based Proteomics, Adv. Exp. Med. Biol., 2016, 919, 345-382 (Book chapter)
  14. Wendong Chen, Shuai Wang, Subash Adhikari, Zuhui Deng, Lingjue Wang, Lan Chen, Mi Ke, Pengyuan Yang, Ruijun Tian, Simple and Integrated Spintip-based Technology Applied for Deep Proteome Profiling, Anal. Chem., 2016, 88, 4864-4871
  15. Peipei Song, Peiwu Huang, Tengjun Huang, Hua Li, Wendong Chen, Lin Lin, Shun Feng, Ruijun Tian, Facile synthesis of carboxymethyl-β-cyclodextrin conjugated magnetic nanoparticles for selective enrichment of glycopeptides, Rapid Commun. Mass Spectrom., 2016, suppl 1, 190-195
  16. Lin Lin ;Luo Shu-Sheng ;Wang Ling-Jue ;Yang Jie ;Shen Hai-Nan ;Tian Rui-Jun‡, Progress and Application of LC-MS Technologies for Characterizing Protein Post Translational Modifications, Chinese J. Anal. Chem., 2015, 43, 1479-1488
  17. Jing Jin*‡, Ruijun Tian*‡, Adrian Pasculescu, Anna Yue Dai, Kelly Williton, Lorne Taylor, Mikhail M. Savitski, Marcus Bantscheff, James R. Woodgett, Karen Colwill, and Tony Pawson, Mutational analysis of GSK3β protein kinase together with kinome-wide binding and stability studies suggest context-dependent recognition of kinases by the chaperone HSP90, Mol. Cell. Biol., 2016, 36, 1007-1018
  18. Ruijun Tian*‡, Haopeng Wang*, Gerald D. Gish, Evangelia Petsalaki, Adrian Pasculescu, Yu Shi, Marianne Mollenauer, Richard D. Bagshaw, Nir Yosef, Tony Hunter, Anne-Claude Gingras, Arthur Weiss‡, Tony Pawson, A combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor, Proc. Natl. Acad. Sci. U. S. A., 2015, 112, E1594–E1603
  19. Ruijun Tian, Exploring intercellular signaling by proteomic approaches, Proteomics, 2014, 14(4-5):498-512 (Direct invitation by Editor-in-chief: Michael Dunn)
  20. Ruijun Tian*, Jing Jin*, Lorne Taylor, Brett Larsen, Susan E. Quaggin, Tony Pawson, Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions, Proteomics, 2013, 13, 1334–1338 (Direct invitation to RT)

- Highlighted as a key scientific article in Global Medical Discovery

  1. Ruijun Tian, Matias Alvarez-Saavedra, Hai-Ying M. Cheng, Daniel Figeys, Uncovering the proteome response of the master circadian clock to light using an AutoProteome system, Mol. Cell. Proteomics, 2011, 11, M110.00725
  2. Ruijun Tian*, Shuai Wang*, Fred Elisma, Li Li, Hu Zhou, Lisheng Wang, Daniel Figeys, Rare cell proteomic reactor applied to stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics study of human embryonic stem cell differentiation, Mol. Cell. Proteomics, 2011, 10, M110.000679 (Cover paper)
  3. Ruijun Tian, He Zhang, Mingliang Ye, Xiaogang Jiang, Lianghai Hu, Xin Li, Xinhe Bao, Hanfa Zou, Selective extraction of peptides from human plasma by highly ordered mesoporous silica particles for peptidome analysis, Angew. Chem. Int. Ed., 2007, 46, 962-965
  4. Ruijun Tian*, Xuyen Dai Hoa*, Jean-Philippe Lambert, John Paul Pezacki, Teodor Veres, Daniel Figeys, Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions, Anal. Chem., 2011, 83, 4095-4102
  5. Ruijun Tian*, Lianbing Ren*, Huaijun Ma, Xin Li, Lianghai Hu, Mingliang Ye, Ren’an Wu, Zhijian Tian, Zhen Liu, Hanfa Zou, Selective enrichment of endogenous peptides by chemically modified porous nanoparticles for peptidome analysis, J. Chromatogr. A, 2009, 1216, 1270-1278
  6. Shuai Wang*, Ruijun Tian*, Li Li, Lisheng Wang, Daniel Figeys, An enhanced chemically defined SILAC culture system for quantitative proteomics study of human embryonic stem cells, Proteomics, 2011, 11, 4040-4046
  7. Ruijun Tian*, Lindong Li*, Wei Tang, Hongwei Liu, Mingliang Ye, Zongbao K. Zhao, Hanfa Zou, Chemical proteomic study of isoprenoid chain interactome with a synthetic photoaffinity probe, Proteomics, 2008, 8, 3094–3104
  8. Ruijun Tian, Mingliang Ye, Xiaogang Jiang, Lianghai Hu, Xin Li, Hanfa Zou, Selective extraction of peptides in acidic human plasma by porous silica nanoparticles for peptidome analysis with 2-D LC-MS/MS, J. Sep. Sci., 2007, 30, 2204-2209
  9. Ruijun Tian, Xinning Jiang, Xin Li, Xiaogang Jiang, Shun Feng, Songyun Xu,Guanghui Han, Mingliang Ye , Hanfa Zou, Biological fingerprinting analysis of the interactome of a kinase inhibitor in human plasma by a chemiproteomic approach, J. Chromatogr. A, 2006, 1134, 134–142
  10. Ruijun Tian, Junming Sun, He Zhang, Mingliang Ye, Chuanhui Xie, Jin Dong, Jiwei Hu, Ding Ma, Xinhe Bao, Hanfa Zou, Large-pore mesoporous SBA-15 silica particles with submicrometer size as stationary phases for high-speed CEC separation, Electrophoresis, 2006, 27, 742–748
  11. Ruijun Tian, Songyun Xu, Xiaoyuan Lei, Wenhai Jin, Mingliang Ye, Hanfa Zou, Characterization of small-molecule-biomicromolecule interactions: From simple to complex, Trac-Trend Anal.Chem., 2005, 24, 810-825

 

Co-author papers:

  1. Song X, Liu W, Yuan X, Jiang J, Wang W, Mullen M, Zhao X, Zhang Y, Liu F, Du S, Rehman A, Tian R, Li J, Frost A, Song Z, Green HN, Henry C, Liu X, Ding X, Wang D, Yao X, Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion. J Mol Cell Biol., 2018, 10, 559-572
  2. Li T, Deng Y, Shi Y, Tian R, Chen Y, Zou L, Kazi JU, Rönnstrand L, Feng B, Chan SO, Chan WY, Sun J, Zhao H, Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene. 2018 Jul 16. doi: 10.1038/s41388-018-0397-7.
  3. Bao X, Liu H, Liu X, Ruan K, Zhang Y, Zhang Z, Hu Q, Liu Y, Akram S, Zhang J, Gong Q, Wang W, Yuan X, Li J, Zhao L, Dou Z, Tian R, Yao X, Wu J, Shi Y, Similar articles Select item 29040603 6. Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation, J Mol Cell Biol. 2018 Feb 1;10(1):18-32
  4. Ying Sun, Chen Guo, Ping Ma, Yumei Lai, Fan Yang, Jun Cai, Zhehao Cheng, Kuo Zhang, Zhongzhen Liu, Yeteng Tian, Yue Sheng, Ruijun Tian, Yi Deng, Guozhi Xiao, and Chuanyue Wu, Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury, J. Am. Soc. Nephrol., 2017, 28, 3545-3562
  5. Duan H, Wang C, Wang M, Gao X, Yan M, Akram S, Peng W, Zou H, Wang D, Zhou J, Chu Y, Dou Z, Barrett G, Green HN, Wang F, Tian R, He P, Wang W, Liu X, Yao X, Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation, J. Biol. Chem., 2016, 291, 21123-21136
  6. Harrod H. Ling, Christian Beaulé, Cheng-Kang Chiang, Ruijun Tian, Daniel Figeys, Hai-Ying M. Cheng, Time-of-Day- and Light-Dependent Expression of Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) in the Suprachiasmatic Nucleus Circadian Clock, PLoS One, 2014, 9, e103103
  7. Adrian Pasculescu, Erwin M. Schoof, Pau Creixellb, Yong Zheng, Marina Olhovsky, Ruijun Tian, Jonathan So, Rachel D. Vanderlaan, Tony Pawson, Rune Linding, Karen Colwill, CoreFlow: A computational platform for integration, analysis and modeling of complex biological data, J. Proteomics, 2014, 100, 167–173
  8. Jing Jin*, Karen Sison*, Chengjin Li, Ruijun Tian, Nina Jones, Dontscho Kerjachki, Masabumi Shibuya, George Fantus, Hanspeter Gerber, Napoleone Ferrara, Tony Pawson, Susan E. Quaggin, Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function, Cell, 2012, 151, 384-399
  9. Chao Xu*, Jing Jin*, Chuanbing Bian, Robert Lam, Ruijun Tian, Ryan Weist, Linya You, Jianyun Nie, Alexey Bochkarev, Wolfram Tempel, Chris S Tan, Gregory A Wasney, Masoud Vedadi, Gerry D. Gish, Cheryl H Arrowsmith, Tony Pawson, Xiang-Jiao Yang, Jinrong Min, Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock, Sci. Signal., 2012, 5, ra39
  10. James Knight, Ruijun Tian, Robin Lee, Fangjun Wang, Hanfa Zou, Lynn Megeney, Daniel Figeys, Rashmi Kothary, A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts, Skeletal Muscle, 2012, 2, 5
  11. Houjiang Zhou, Fred Elisma, Nicholas J. Denis, Theodore G. Wright, Ruijun Tian, Hu Zhou, Weimin Hou, Hanfa Zou, Daniel Figeys, Analysis of the Subcellular Phosphoproteome Using a Novel Phosphoproteomic Reactor, J. Proteome Res., 2010, 9, 1279-1288
  12. Hu Zhou, Weimin Hou, Jean-Philippe Lambert, Ruijun Tian, Daniel Figeys, Analysis of low-abundance proteins using the proteomic reactor with pH fractionation, Talanta, 2010, 80, 1526-1531
  13. Mohamed Abu-Farha, Fred Elisma*, Houjiang Zhou*, Ruijun Tian*, Hu Zhou*, Mehmet Selim Asmer and Daniel Figeys, Proteomics: From Technology Developments to Biological Applications, Anal. Chem., 2009, 81, 4585–4599
  14. Fangjun Wang, Mingliang Ye, Jing Dong, Ruijun Tian, Lianghai Hu, Guanghui Han, Xinning Jiang, Ren'an Wu, Hanfa Zou, Improvement of performance in label-free quantitative proteome analysis with monolithic electrospray ionization emitter, J. Sep. Sci., 2008, 31, 2589 – 2597
  15. Liang Zhao, Ren'an Wu, Guanghui Han, Houjiang Zhou, Lianbing Ren, Ruijun Tian, Hanfa Zou, The highly selective capture of phosphopeptides by zirconium phosphonate-modified magnetic nanoparticles for phosphoproteome analysis, J. Am. Soc. Mass. Spectrom., 2008, 19, 1176-1186
  16. Guanghui Han, Mingliang Ye, Houjiang Zhou, Xinning Jiang, Shun Feng, Xiaogang Jiang, Ruijun Tian, Dafang Wan, Hanfa Zou, Jianren Gu, Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography, Proteomics, 2008, 8, 1346-1361
  17. Houjiang Zhou, Ruijun Tian, Mingliang Ye, Songyun Xu, Shun Feng, Chensong Pan, Xiaogang  Jiang, Xin Li, Hanfa Zou, Highly specific enrichment of phosphopeptides by zirconium dioxide nanoparticles for phosphoproteome analysis, Electrophoresis, 2007, 28, 2201–2215
  18. Xiaogang Jiang, Shun Feng, Ruijun Tian, Guanghui Han, Xinning Jiang, Mingliang Ye, Hanfa Zou, Automation of nanoflow liquid chromatography-tandem mass spectrometry for proteome analysis by using a strong cation exchange trap column, Proteomics, 2007,7,528–539
  19. Xiaogang Jiang, Xinning Jiang, Shun Feng, Ruijun Tian, Mingliang Ye, Hanfa Zou, Development of Efficient Protein Extraction Methods for Shotgun Proteome Analysis of Formalin-Fixed Tissues, J. Proteome Res., 2007, 6, 1038-1047
  20. Fangjun Wang, Xiaogang Jiang, Shun Feng, Ruijun Tian, Xinning Jiang, Guanghui Han, Hongwei Liu, Mingliang Ye, Hanfa Zou, Automated injection of uncleaned samples using a ten-port switching valve and a strong cation-exchange trap column for proteome analysis, J. Chromatogr. A, 2007, 1171, 56-62
  21. Mingliang Ye, Xiaogang Jiang, Shun Feng, Ruijun Tian, Hanfa Zou, Advances in chromatographic techniques and methods in shotgun proteome analysis, Trac-Trend Anal.Chem., 2007, 26, 80-84
  22. Jiwei Hu, Chuanhui Xie, Ruijun Tian, Zhike He, Hanfa Zou, Separation of basic and acidic compounds by capillary electrochromatography using monolithic silica capillary columns with zwitterionic stationary phase, J. Sep. Sci., 2007, 30, 891-899
  23. Junming Sun, He Zhang, Ruijun Tian, Ding Ma, Xinhe Bao, Dang Sheng Su, Hanfa Zou, Ultrafast enzyme immobilization over large-pore nanoscale mesoporous silica particles, Chem. Commun., 2006, 1322-1324
  24. Jiwei Hu, Chuanhui Xie, Ruijun Tian, Zhike He, Hanfa Zou, Hybrid silica monolithic column for capillary electrochromatography with enhanced cathodic electroosmotic flow, Electrophoresis, 2006, 27, 4266–4272
  25. Jing Dong, Chuanhui Xie, Ruijun Tian, Renan Wu, Jiwei Hu, Hanfa Zou, Capillary electrochromatography with a neutral monolithic column for classification of analytes and determination of basic drugs in human serum, Electrophoresis, 2005, 26, 3452–3459
  26. Chuanhui Xie, Jiwei Hu, Hua Xiao, Xingye Su, Jing Dong, Ruijun Tian, Zhike He, Hanfa Zou, Preparation of monolithic silica column with strong cation-exchange stationary phase for capillary electrochromatography, J. Sep. Sci., 2005, 28, 751-756
  27. Chuanhui Xie, Jiwei Hu, Hua Xiao, Xingye Su, Jing Dong, Ruijun Tian, Zhike He, Hanfa Zou, Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals, Electrophoresis, 2005, 26, 790-797