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肖荣权
研究助理教授
xiaorq@sustech.edu.cn

个人简介:

肖荣权,南方科技大学医学院研究助理教授。2020年获得厦门大学理学博士学位,导师为刘文教授。主要从事癌症等重大疾病的表观遗传分子机制及其应用研究。研究工作发表于Molecular Cell,Proc Natl Acad Sci U S A和ACS Medicinal Chemistry Letters等国际学术期刊。主持国家自然科学基金青年科学基金项目、中国博士后科学基金面上资助(二等)和深圳市医学研究专项资金项目(人才提升型-青年项目)各1项。申请专利4项,其中3项已经获得授权。

 

教育背景:

2014/09 - 2020/06 厦门大学, 化学生物学, 博士

2009/09 - 2013/07 上海师范大学, 生物技术, 学士

 

工作经历:

2023/06 - 至今  南方科技大学, 医学院, 研究助理教授

2020/07 - 2023/06 厦门大学, 药学院,博士后

 

获奖情况及荣誉:

厦门大学生命科学与人类健康学科群2021年度优秀博士后资助,2021

厦门大学“优秀毕业生”荣誉称号,2020

厦门大学药学院“庄瑾奖学金”突出贡献奖,2018

 

研究领域:

表观遗传调控因子在肿瘤中的功能、分子机制及其应用研究

 

发表论文:

1. Xiao RQ, Ran T, Huang QX, Hu GS, Fan DM, Yi J, Liu W. A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34): e2200753119.

2. Gao WW#, Xiao RQ#, Zhang WG#, Hu YR#, Peng BL, Li WJ, He YH, Shen HF, Ding JC, Huang QX, Ye TY, Li Y, Liu ZY, Ding R, Rosenfeld MG, Liu W. JMJD6 licenses estrogen receptor a-dependent enhancer and coding gene activation by modulating the recruitment of the CARM1/MED12 co-activator complex. Molecular Cell. 2018 April 19;70(2): 340-357. (# 共同第一作者)

3. Ran T#, Xiao RQ#, Huang QX, Yuan HL, Lu T, Liu W. In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment. ACS Medicinal Chemistry Letters. 2019 Nov 19, 10: 1609-1613. (# 共同第一作者)

4. Gao WW, Xiao RQ, Peng BL, Xu HT, Shen HF, Huang MF, Shi TT, Yi J, Zhang WJ, Wu XN, Gao X, Lin XZ, Dorrestein PC, Rosenfeld MG, Liu W. Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26): E3327-36.

5. Yi J, Wang L, Du J, Wang MY, Shen HF, Liu ZY, Qin Y, Liu J, Hu GS, Xiao RQ, Ding JC, Chen HJ, Wang HJ, Huang HH, Ouyang GL, Liu W. ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer. Developmental Cell. 2023 May 8, 58(9): 760-778.

6. Peng BL, Li WJ, Ding JC, He YH, Ran T, Xie BL, Wang ZR, Shen HF, Xiao RQ, Gao WW, Ye TY, Gao X, Liu W. A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor a-dependent transcriptional activation and breast carcinogenesis. Theranostics. 2020 Feb 10; 10(8): 3451-3473.

7. Zhang WJ, Wu XN, Shi TT, Xu HT, Yi J, Shen HF, Huang MF, Su XY, Wang FF, Peng BL, Xiao RQ, Gao WW, Ding JC, Liu W. Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation. Scientific Reports. 2016 Feb 23; 6: 21718.

8. Ye F, You J, Xia L, Lian JB, Xiao RQ, Ran T, Gao X, Li JY, Zhao X, Gao J, Lin HX, Zheng JN, Liu W. Patient-derived xenografts (PDX) identify JMJD6 inhibitor as an effective therapeutic medicine in colorectal cancer. Annals of Oncology. 2019 Oct; 30: v238-v239.