个人简介：

夏思源，2014年毕业于南开大学，获得生物化学与分子生物学博士学位。毕业后赴美国Emory大学医学院血液与医学肿瘤学系进行博士后工作，后晋升为Associate Research Scientist。2021年8月全职回国，加入南方科技大学医学院，任助理教授，博士生导师。研究方向主要集中于肿瘤代谢与肿瘤免疫领域，研究内容主要包括代谢物在肿瘤微环境中的作用，肿瘤代谢通路的调节与靶向。在生物化学，分子生物学，肿瘤细胞生物学与免疫学方面具有深厚的专业基础。截止目前，已在Cell Metabolism、Cancer Discovery、Molecular Cell、Journal of Immunology等高水平国际期刊发表论文24篇，总引用近800余次，并获得专利1项。同时，作为审稿人多次为Journal of Cellular Physiology，Journal of Genetics and Genomics，Scientific Reports和Oncotarget等杂志审稿。未来的研究将主要聚焦于代谢物对肿瘤微环境的调控，构建综合性代谢物文库，筛选调控肿瘤细胞、免疫细胞与基质细胞相互作用的代谢物，明确其作用机制及靶向策略，探讨其与免疫治疗的联合应用。

教育背景：

2005.9 ~ 2009.6: 南开大学，生物科学，本科      

2009.9 ~ 2014.6: 南开大学，生物化学与分子生物学，直博

工作经历：

2014.9 ~ 2019.8: 美国Emory大学，血液与医学肿瘤学系，博士后

2019.9 ~ 2021.1: 美国Emory大学，血液与医学肿瘤学系，  Associate Research Scientist  

2021.8 ~ 至今： 南方科技大学，医学院，人类细胞生物和遗传学系，助理教授 

研究领域：

1. 代谢物作为信号分子对肿瘤细胞的调控作用

2. 肿瘤转移灶的代谢微环境以及对肿瘤细胞与免疫细胞的影响

3. 代谢物作为潜在靶点与肿瘤免疫治疗的联合应用

学术任职：

2018 至今：美国癌症研究协会（AACR）,  Associate Member

2017 至今：美国血液学会（ASH）， Associate Member

发表论文： *共同第一作者，#共同通讯作者

• Xue Gao, Yijie Liu, Yuancheng Li, Hao Fan, Rong Wu, Rukang Zhang, Brandon Faubert, Yu-Ying He, Marc B. Bissonnette, Siyuan Xia, Dong Chen, Hui Mao, Titus J. Boggon, and Jing Chen. Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation. Molecular cell, Molecular cell, S1097-2765(22)00264-7. 7 Apr. 2022, doi:10.1016/j.molcel.2022.03.026 (2022).

• Siyuan Xia, Ruiting Lin, Lingtao Jin, Liang Zhao, Hee-Bum Kang,      Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian, Evmorfia      Konstantakou, Baotong Zhang, Jin-Tang Dong, Young Rock Chung, Omar      Abdel-Wahab, Taha Merghoub, Lu Zhou, Ragini R. Kudchadkar, David H.      Lawson, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar Lonial,      Benjamin H. Lee, Brian P. Pollack, Jack L. Arbiser, Jun Fan, Qun-Ying Lei      & Jing Chen. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates      BRAF V600E Tumor Growth. Cell Metab 25, 358-373,      doi:10.1016/j.cmet.2016.12.010 (2017).

• Dong Chen*, Siyuan Xia*, Mei Wang*, Ruiting Lin, Yuancheng Li,      Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W.      Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina      Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra,      Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J.      Boggon, Ross L. Levine#, Jing Chen#. Mutant and Wild-Type Isocitrate      Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine      Kinase Cascades in Cancer. Cancer Discov, doi:10.1158/2159-8290.CD-18-1040      (2019).

• Dong Chen*, Siyuan Xia*, Rukang Zhang*, Yuancheng Li,      Christopher A. Famulare, Hao Fan, Rong Wu, Mei Wang, Allen C. Zhu, Shannon      E. Elf, Rui Su, Lei Dong, Martha Arellano, William G. Blum, Hui Mao, Sagar      Lonial, Wendy Stock, Olatoyosi Odenike, Michelle Le Beau, Titus J. Boggon,      Chuan He, Jianjun Chen, Xue Gao#, Ross L. Levine#, and Jing Chen#. Lysine      acetylation restricts mutant IDH2 activity to optimize transformation in      AML cells. Mol Cell, 81, 1-15, doi: 10.1016/j.molcel.2021.06.027 (2021)

• Siyuan Xia*, Jun Wei*, Jingya Wang, Huayan Sun, Wenting Zheng,      Yangguang Li, Yanbo Sun, Huiyuan Zhao, Song Zhang, Ti Wen, Xinglong Zhou,      Jian-Xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Zhinan Yin. A      requirement of dendritic cell-derived interleukin-27 for the tumor      infiltration of regulatory T cells. J Leukoc Biol 95, 733-742,      doi:10.1189/jlb.0713371 (2014).

• Jun Wei*, Siyuan Xia*, Huayan Sun, Song Zhang, Jingya Wang,      Huiyuan Zhao, Xiaoli Wu, Xi Chen, Jianlei Hao, Xinglong Zhou, Zhengmao      Zhu, Xiang Gao, Jian-Xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, Zhinan      Yin. Critical role of dendritic cell-derived IL-27 in antitumor immunity      through regulating the recruitment and activation of NK and NKT cells. J      Immunol 191, 500-508, doi:10.4049/jimmunol.1300328 (2013).

• Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick,      Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei-Ping Qian,      Lily Yang, Adeboye O. Osunkoya, Lawrence H. Boise, Paula M. Vertino,      Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Jin-Tang Dong.      Acetylation of KLF5 maintains EMT and tumorigenicity to cause      chemoresistant bone metastasis in prostate cancer. Nat Commun. 12, 1714,      doi: 10.1038/s41467-021-21976-w (2021).

• Baotong Zhang,Siyuan Xia, Mingcheng Liu, Xiawei      Li, Shimin Shuai, Wei Tao, Yixiang Li, Jianping Jenny      Ni, Wei Zhou, Lan Liao, Jianming Xu, Jin-Jang Dong.      Interruption of Klf5 acetylation in basal progenitor cells promotes      luminal commitment by activating Notch signaling. Journal of genetics and      genomics 21, doi:10.1016/j.jgg.2021.11.013 (2021).

• Baotong Zhang, Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan      Xuan, Jamie L. King, Siyuan Xia, Yixiang Li, Henry F. Frierson, Dong-Kee      Lee, Jianming Xu, Adeboye O. Osunkoya, Jin-Tang Dong. Klf5 acetylation      regulates luminal differentiation of basal progenitors in prostate      development and regeneration. Nat Commun 11, 997,      doi:10.1038/s41467-020-14737-8 (2020).

• Yixiang Li, Baotong Zhang#, Lingwei Xiang, Siyuan Xia, Omer      Kucuk, Xingming Deng, Lawrence H. Boise, Jin-Tang Dong#. TGF-beta causes      Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by      acetylated KLF5 and Protein Stabilization. Theranostics 10, 7656-7670,      doi:10.7150/thno.44567 (2020).

• Yuancheng Li, Hui Wu, Bing Ji, Weiping Qian, Siyuan Xia, Liya Wang,      Yaolin Xu, Jing Chen, Lily Yang, Hui Mao. Targeted Imaging of CD206      Expressing Tumor-Associated M2-like Macrophages Using Mannose-Conjugated      Antibiofouling Magnetic Iron Oxide Nanoparticles. ACS Applied Bio      Materials 3, 4335-4347, doi:10.1021/acsabm.0c00368 (2020).

• Xue Gao*, Liang Zhao*, Shuangping Liu*, Yuancheng Li, Siyuan      Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren      Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J.      Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang Shan,      Jing Chen. gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative      Pentose Phosphate Pathway, Contributes to AMPK Activation through      Inhibition of PP2A. Mol Cell 76, 857- 871 e859,      doi:10.1016/j.molcel.2019.09.007 (2019).

• Ran Tao*, Baotong Zhang*, Yixiang Li, Jamie L. King, Ruoyu      Tian, Siyuan Xia, Cara Rae Schiavon, Jin-Tang Dong. HDAC-mediated      deacetylation of KLF5 associates with its proteasomal degradation. Biochem      Biophys Res Commun 500, 777-782, doi:10.1016/j.bbrc.2018.04.153 (2018).

• Ruiting Lin, Siyuan Xia, Changliang Shan, Dong Chen, Yijie Liu,      Xue Gao, Mei Wang, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Young Rock      Chung, Omar Abdel-Wahab, Taha Merghoub, Michael Rossi, Ragini R.      Kudchadkar, David H. Lawson, Fadlo R. Khuri, Sagar Lonial, Jing Chen. The      Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific      Pro-tumor Effects on BRAF V600E Melanoma Cells. Mol Cell 69, 923-937,      doi:10.1016/j.molcel.2018.02.010 (2018).

• Liang Zhao, Jun Fan, Siyuan Xia, Yaozhu Pan, Shuangping Liu,      Guoqing Qian, Zhiyu Qian, Hee-Bum Kang, Jack L. Arbiser, Brian P. Pollack,      Ragini R. Kudchadkar, David H. Lawson, Michael Rossi, Omar Abdel-Wahab,      Taha Merghoub, Hanna J. Khoury, Fadlo R. Khuri, Lawrence H. Boise, Sagar      Lonial, Fangping Chen#, Jing Chen#, Ruiting Lin. HMG-CoA synthase 1 is a      synthetic lethal partner of BRAF(V600E) in human cancers. J Biol Chem 292,      10142-10152, doi:10.1074/jbc.M117.788778 (2017).

• Shannon Elf*, Ruiting Lin*, Siyuan Xia, Yaozhu Pan, Changliang      Shan, Shaoxiong Wu, Sagar Lonial, Manila Gaddh, Martha L. Arellano, Hanna      J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Titus J. Boggon, Jun Fan, Jing      Chen. Targeting 6- phosphogluconate dehydrogenase in the oxidative PPP      sensitizes leukemia cells to antimalarial agent dihydroartemisinin.      Oncogene 36, 254-262, doi:10.1038/onc.2016.196 (2017).

• Qian Zhang, Jian Mao, Xiaoxi Zhang, Haifeng Fu, Siyuan Xia,      Zhinan Yin, Lin Liu. Role of Jnk1 in development of neural precursors      revealed by iPSC modeling. Oncotarget 7, 60919-60928,      doi:10.18632/oncotarget.11377 (2016).

• Jun Fan*#, Ruiting Lin*, Siyuan Xia, Dong Chen, Shannon E. Elf,      Shuangping Liu, Yaozhu Pan, Haidong Xu, Zhiyu Qian, Mei Wang, Changliang      Shan, Lu Zhou, Qun-Ying Lei, Yuancheng Li, Hui Mao, Benjamin H. Lee,      Jessica Sudderth, Ralph J. DeBerardinis, Guojing Zhang, Taofeek Owonikoko,      Manila Gaddh, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Sumin      Kang, Paul W. Doetsch, Sagar Lonial, Titus J. Boggon, Walter J. Curran,      Jing Chen#. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for      Tumor Growth. Mol Cell 64, 859-874, doi:10.1016/j.molcel.2016.10.014      (2016).

• Xin Li, Baotong Zhang, Qiao Wu, Xinpei Ci, Ranran Zhao, Zhiqian      Zhang, Siyuan Xia, Dan Su, Jie Chen, Gui Ma, Liya Fu, Jin-Tang Dong.      Interruption of KLF5 acetylation converts its funciton from tumor      suppressor to tumor promoter in prostate cancer cells. Int J Cancer 136,      536-546, doi:10.1002/ijc.29028 (2015).

• Song Zhang, Ruifang Liang, Wei Luo, Chang Liu, Xiaoli Wu, Yanan      Gao, Jianlei Hao, Guangchao Cao, Xi Chen, Jun Wei, Siyuan Xia, Zheng Li,      Ti Wen, Yunyun Wu, Xinglong Zhou, Puyue Wang, Liqing Zhao, Zhenzhou Wu,      Sidong Xiong, Xiaoming Gao, Xiang Gao, Yongyan Chen, Qing Ge, Zhigang      Tian, Zhinan Yin. High susceptibility to liver injury in IL-27 p28 conditional      knockout mice involves intrinsic interferon-gamma dysregulation of CD4+ T      cells. Hepatology 57, 1620- 1631, doi:10.1002/hep.26166 (2013).

• Baotong Zhang, Zhiqian Zhang, Siyuan Xia, Changsheng Xing,      Xinpei Ci, Xin Li, Ranran Zhao, Sha Tian, Gui Ma, Zhengmao Zhu, Liya Fu,      Jin-Tang Dong. KLF5 activates microRNA 200 transcription to maintain      epithelial characteristics and prevent induced epithelial-mesenchymal      transition in epithelial cells. Mol Cell Biol 33, 4919-4935,      doi:10.1128/MCB.00787-13 (2013).

• Xiaoli Wu*, Ji-Yuan Zhang*, Ang Huang, Yuan-Yuan Li, Song      Zhang, Jun Wei, Siyuan Xia, Yajuan Wan, Weiwei Chen, Zheng Zhang,      Yangguang Li, Ti Wen, Yan Chen, Yoshimasa Tanaka, Youjia Cao, Puyue Wang,      Liqing Zhao, Zhenzhou Wu, Fu-Sheng Wang, Zhinan Yin. Decreased V delta 2      gamma delta T cells associated with liver damage by regulation of Th17      response in patients with chronic hepatitis B. J Infect Dis 208,      1294-1304, doi:10.1093/infdis/jit312 (2013).

• Yangguang Li, Ti Wen, Minzhi Zhu, Lixin Li, Jun Wei, Xiaoli Wu,      Mingzhou Guo, Shuangping Liu, Huiyuan Zhao, Siyuan Xia, Weili Huang, Puyue      Wang, Zhenzhou Wu, Liqing Zhao, Wenqing Shui#, Zheng Li#, Zhinan Yin#.      Glycoproteomic analysis of tissues from patients with colon cancer using      lectin microarrays and nanoLC-MS/MS. Mol Biosyst 9, 1877-1887,      doi:10.1039/c3mb00013c (2013).

• Jianlei Hao, Siyuan Dong, Siyuan Xia, Weifeng He, Hao Jia, Song      Zhang, Jun Wei, Rebecca L. O’Brien, Willi K.      Born, Zhenzhou Wu, Puyue Wang, Jihong Han, Zhangyong Hong, Liqing Zhao,      Zhinan Yin. Regulatory role of Vgamma1 gammadelta T cells in tumor      immunity through IL-4 production. J Immunol 187, 4979-4986,      doi:10.4049/jimmunol.1101389 (2011).

•  Jianlei Hao, Xiaoli Wu, Siyuan Xia, Zheng Li, Ti Wen, Na      Zhao, Zhenzhou Wu, Puyue Wang, Liqing Zhao, Zhinan Yin. Current progress      in gammadelta T-cell biology. Cell Mol Immunol 7, 409-413,      doi:10.1038/cmi.2010.50 (2010).