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陶丽芝
副教授
taolz@sustech.edu.cn

陶丽芝,南方科技大学化学系副教授、博士生导师、课题组长。2011年于清华大学化学系获硕士学位 (导师:徐柏庆教授),研究方向为固体酸碱多相催化化学。之后前往美国加州大学戴维斯分校 (University of California, Davis) 全球著名电子顺磁共振光谱 (Electron Paramagnetic Resonance, EPR) 实验室攻读博士学位 (导师:R. David Britt 教授; William H. Casey 教授) ,研究方向为运用电子顺磁共振光谱研究多铜氧化酶催化反应的分子机制。2016年获得博士学位后留校从事博士后研究工作,将研究拓展至多种纷繁复杂的化学以及生物化学体系当中;运用电子顺磁共振光谱EPR对这些体系中的关键顺磁物种进行三维结构鉴定和解析,获得了原子、分子层面上反应机理及构效关系的认识和理解。迄今为止,在领域内顶级国际学术刊物 (J. Am. Chem. Soc., Nature Chem., Nature Rev. Chem.等) 发表论文40余篇。2021年入选海外高层次人才计划青年项目,2022年7月加入南方科技大学化学系。

 

研究方向:

1. 先进电子顺磁共振光谱Advanced Electron Paramagnetic Resonance, EPR;

2. 金属蛋白酶催化反应机理研究;

3. 金属有机、表面多相催化化学反应分子机制。


代表性论文:

[10] Y. Zhang#, L. Tao# (co-first author), T. Woods, R. D. Britt and T. B. Rauchfuss, “Organometallic Fe2(μ-SH)2(CO)4(CN)2 cluster allows the biosynthesis of the [FeFe]-hydrogenase with only the HydF maturase”, J. Am. Chem. Soc., 2022, 144, 1534-1538.

[9] R. D. Britt*, G. Rao* and L. Tao*, “Bioassembly of complex iron–sulfur enzymes: hydrogenases and nitrogenases”, Nat. Rev. Chem., 2020, 4, 542-549.

[8] L. Tao, S. A. Pattenaude, S. Joshi, T. P. Begley, T. B. Rauchfuss and R. D. Britt, “Radical SAM enzyme HydE generates adenosylated Fe(I) intermediates en route to the [FeFe]-hydrogenase catalytic H-cluster”, J. Am. Chem. Soc., 2020, 142, 10841-10848.

[7] L. Tao, T. Y. Lai, P. P. Power and R. D. Britt, “Germanium hydride radical trapped during the photolysis/thermolysis of diarylgermylene”, Inorg. Chem., 2019, 58, 15034-15038.

[6] L. Tao, W. Zhu, J. P. Klinman and R. D. Britt, “Electron paramagnetic resonance spectroscopic identification of the Fe–S clusters in the SPASM domain-containing radical SAM enzyme PqqE”, Biochemistry, 2019, 58, 5173-5187.

[5] L. Tao, T. A. Stich, C. J. Fugate, J. T. Jarrett and R. D. Britt, “EPR-derived structure of a paramagnetic intermediate generated by biotin synthase BioB”, J. Am. Chem. Soc., 2018, 140, 12947-12963.

[4] L. Tao, T. A. Stich, W. H. Casey, R. D. Britt, et al., “Copper binding sites in the manganese-oxidizing Mnx protein complex investigated by electron paramagnetic resonance spectroscopy”, J. Am. Chem. Soc., 2017, 139, 8868-8877.

[3] L. Tao, T. A. Stich, W. H. Casey, R. D. Britt, et al., “Mn(II) binding and subsequent oxidation by the multicopper oxidase MnxG investigated by electron paramagnetic resonance spectroscopy”, J. Am. Chem. Soc., 2015, 137, 10563-10575. 

[2] L. Tao, S.-H. Chai, H.-P. Wang, B. Yan, Y. Liang and B.-Q. Xu, “Comparison of gas-phase dehydration of propane polyols over solid acid–base catalysts”, Catal. Today, 2014, 234, 237-244.

[1] L. Tao, B. Yan, Y. Liang and B.-Q. Xu, “Sustainable production of acrolein: catalytic performance of hydrated tantalum oxides for gas-phase dehydration of glycerol”, Green Chem., 2013, 15, 696-705.