师资

何振宇
副教授
0755-88018318
jasonhcy@sustech.edu.cn

何振宇博士于2000年-2005年在香港大学(the university of hong kong)化学系杨丹教授指导下从事有机不对称催化并获得博士学位,随后在麻省理工学院(M.I.T.) prof. timothy f. jamison研究组作为博士后从事过渡金属催化。从2007年底开始,在香港中文大学(the chinese university of hongkong)作为研究助理教授开始了独立的研究,从2013年起,加盟深圳南方科技大学(SUSTech),入选深圳市孔雀计划b类人员,主要从事金属有机化学n-杂环卡宾及其在有机金属催化中的应用研究,在国内外学术刊物(angew. chem. int. ed, j. am.chem. soc,chem. commun., acs catal.等)发表论文多篇,并获the asian core program lectureship award (from japan),the asian core program lectureship award (from singapore)等多项奖项。

 

近年来的文章:
A/ US Non-Provisional Patent granted or filed (As the sole inventor):
1. Ho, C.-Y. US8354554B2 “Process for Preparing Organometalloids”
2. Ho, C.-Y. US8383873B2 “Terminal 1,1-Disubstituted Olefin, Methods of Making & Using Thereof”
3. Ho, C.-Y. US regular patent filed, application number: 13/415304, title remains confidential
4. Ho, C.-Y. PCT filed, application number: PCT/CN2014/082861, “Process for Preparing Branched Allyl Compounds”
5. Ho, C.-Y. PCT filed, application number: PCT/CN2015/071187, title remains confidential

B/ Invited Review (As corresponding author):
1. “NHC-Ni-H Reactions with Simple Olefins: Advances in Hydroalkenylation, Polymerization, and Ionic Liquid Synthesis.”
Ho, C.-Y.*; He, L.; Chan, C.-W. Synlett 2011, SynPacts issue, 1649.
2. “Catalytic Addition of Simple Alkenes to Carbonyl Compounds Using Group 10 Metals” Ho, C.-Y.*; Schleicher, K. D.; Chan, C.-W.; Jamison, T. F.* Synlett 2009, 2565.

C/ Book Chapter:
1. “NHC-Ni Hydride Catalyzed Terminal Disubstituted Alkene Synthesis”
Ho, C.-Y.*; He, L. ISBN 978-3-8465-0051-4, 88pgs.
2. “Introduction to General, Organic and Biological Chemistry” Global Edition

D/ Paper (Since 2005):
a/ Catalysis having C-C Bond Formation
1. “Catalytic Asymmetric Hydroalkenylation of Vinylarenes: Electronic Effects of Substrates and Chiral N-Heterocyclic Carbene Ligands”
Ho, C.-Y.*; Chan, C.-W.; He, L. Angew. Chem. Int. Ed. 2015, 54, 4512.
Highlighted thrice:
Featured as Front Cover & VIP (Very Important Paper), in Angew. Chem. Int. Ed. 2015, 54 (15), 4403. in ChemCatChem 2015, 7, 1639 by Prof. Gerhard Hilt & in X-Mol on 2015-04-17
2. “Substituted 1,3-cyclohexadiene synthesis by NHC-Nickel(0) catalyzed [2+2+2] cycloaddition of 1,n-Enyne” Zhao, J.-P.; Chan, S.-C.; Ho, C.-Y.* Tetrahedron 2015, 71, 4426.
Invited Special Symposium-in-Print: Progress in organic synthesis: New reactions, strategies and targets.
3. “Medium-Sized Heterocycle Synthesis by the Use of Synergistic Effects of Ni-NHC and γ? Coordination in Cycloisomerization.”
Ho, C.-Y.*; He, L. J. Org. Chem. 2014, 79, 11873.
Invited Special Issue:
(1 of 37 from over 14 countries)
Highlighted twice:
SynFacts 2014, 10, 913 (by Prof. V. Snieckus)
Organic Chemistry Highlights, 2015, (by Prof. D. F. Taber)
“C-O Ring Construction”.
4. “Nitrate-Enhanced NHC-NiH Catalyzed Tail-to-Tail Vinyl Ether Dimerization.”
He, L.; Ho, C.-Y.* Synlett 2014, 25, 2738.
Invited Special Issue: Catalysis with Sustainable Metals. (1 of 18 papers)
5. “Shuffle off the Classic β-Si Elimination by Ni-NHC Cooperation:
Implication for C-C Forming Reactions Involving Ni-Alkyl-β-Silanes.”
Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481.
Honored in Emerging Investigator Issue (1 of 71 papers in the year)
Has been recommended on PubMed advanced by Novo Nordisk?
6. “Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styrenes with alpha Olefins:
Regioselective Migratory Insertion Controlled by a Nickel/N-Heterocyclic Carbene.”
Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182.
Highlighted thrice:
SynForm 2011, issue 2, A15-16 & as Cover (by Prof. M. Zanda);
SynFacts 2011, issue 3, 310 (by Prof. P. Knochel);
Organic Chemistry Highlights, 2011 (by Prof. D. F. Taber)
“Functionalization & Homologation of Alkenes”.
7. “Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN Mediated Chromanols Synthesis
with High cis-Selectivity at room temperature.”
Ho, C.-Y.* Chem. Commun. 2010, 46, 466.
8. “Nitrile assisted, Bronsted acid catalyzed regio and stereoselective diarylphosphonylation of allyl
silyl ethers.”
Ho, C.-Y.*; Chan, C.-W.; Wo, S.-K.; Zuo, Z.; Chan, L.-Y. Org. Biomol. Chem. 2010, 8, 3480.
9. “Alpha Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions.”
Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893.
10. “Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3: Synergy
Between a Strong σ-Donor and a Strong π-Acceptor.”( Hot Paper)
Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2007, 46, 782.
11. “Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates.”
Ng, S.-S.; Ho, C.-Y.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 11513.
12. “Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for Alpha Olefins and More Efficient
with Electron-Rich Aldehydes.”
Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326.
b/ Catalysis having C-Heteroatom Bond Formation
1. “Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by
InCl3/Et3SiH/MeOH System.”
Lee, O.-Y.; Law, K.-L.; Ho, C.-Y.; Yang, D.* J. Org. Chem. 2008, 73, 8829.
2. “Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation of Olefins with Oxone.”
Ho, C.-Y.; Chen, Y.-C.; Wong, M.-K.; Yang, D.* J. Org. Chem. 2005, 70, 898.
c/ Collaborative Pharmaceutical Research Papers Published:
1. "Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as
acetylcholinesterase inhibitors."
Qian, S.; He, L.; Mak, M.; Han, Y.; Ho, C.-Y.*; Zuo, Z.* Int. J. Pharmaceutics, 2014, 477, 442.
2. "In Vitro Anti-acetylcholinesterase Activities and Permeabilities of Novel Potential
Anti-Alzheimer's Agents".
Qian, S.; Mak, M.; He, L.; Ho, C.-Y.*; Han, Y.*; Zuo, Z.*
Paper presented in the 9th International ISSX Meeting, organized by International Society for the
Study of Xenobiotics, 1 pgs. Istanbul, Turkey, 2010.09.04.
3. "Structure-activity and structure-permeability relationships of novel anti-Alzheimer’s agents
tacrine dimers".
Qian, S.; He, L.; Mak, M.; Ho, C.-Y.*; Han, Y.*; Zuo, Z.* Paper presented in the 2011 AAPS
Annual Meeting and Exposition, organized by The American Association of Pharmaceutical
Scientists, 1 pgs. Washington, DC, USA, 2011.10.26.
4. "Development of LC/MS/MS method for determination of a novel tacrine dimer HLS-3 in rat
plasma and its application to pharmacokinetic study".
Qian, S.; He, L.; Wo, S-K.; Mak, M.; Han, Y.*; Ho, C-Y.*; Zuo, Z.* Paper presented in the
2012 AAPS Annual Meeting and Exposition, organized by The American Association of
Pharmaceutical Scientists, USA, 2012.10.14.

(IV) Professional Services:
* Serve as reviewer of the following journals:
Angewandte Chemie International Edition
Chemistry An Asian Journal
Chemistry An European Journal
Journal of the American Chemical Society (JACS)
Journal of Organometallic Chemistry
Organic Letters
Organic and Biomolecular Chemistry
RSC Advance
Synthesis
Synlett
* Serve as an Editorial member of the Journal below:
Natural Products Chemistry & Research Journal

(V) Graduate Students Training
Awards the Trained Graduate Students Received in our Group:
* 1 Asian Core Program (ACP), Junior Workshop on Cutting-Edge Organic Chemistry in Asia
Poster Award (2010).
* 1 Hong Kong Graduate Symposium Poster Award (Organic Chemistry Section).
Awarded by Hong Kong Graduate Symposium Committee (2011)
* 1 Hong Kong PhD Fellowship. Awarded by UGC (2011)
* 1 Student awarded Madam Wong Siew Khoon Scholarship, nominated by the Science Faculty
Scholarship Committee as CUHK representative (2012).
* 1 Student awarded Faculty of Science Postgraduate Student Research Output Award (2012, one
Award in each year).

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