个人简介：

李雪松，生命科学学院助理教授，博士生导师。2013年本科毕业于浙江大学光电信息工程学系，2018年获香港科技大学电子及计算机工程学博士学位。2018-2022年于美国国立卫生研究院（NIH）国家生物医学成像和生物工程研究所（NIBIB） Hari Shroff 实验室从事博士后研究。2022-2026年于霍华德·休斯医学研究所珍妮利亚研究园（HHMI, Janelia Research Campus）担任研究员。2026年8月全职回国加入南方科技大学生命科学学院。长期从事新型光学显微成像技术研究，围绕“活体生物样品高时空分辨率成像”这一核心科学问题，研究方向包括超分辨荧光显微镜、深度学习计算成像和多模态非线性显微成像。近年来在Nature Biotechnology, Nature Methods, Nature Communications, JACS, PNAS等国际权威学术期刊发表论文20余篇，并长期担任Nature Methods, Nature Communications等国际期刊审稿人。

研究领域： 

1. 多视角高时空分辨率显微成像技术及其应用

2. AI辅助计算显微成像

3. 三维结构光超分辨显微成像技术

4. 光片、共聚焦、光子重分配显微镜开发及其应用

工作经历：

2026.08 - 至今，南方科技大学生命科学学院，助理教授

2022.09 - 2026.07，霍华德·休斯医学研究所珍妮利亚研究园，研究员

2018.10 – 2022.09，美国国立卫生研究院，博士后

学习经历：

2013.09 - 2018.07，香港科技大学，电子及计算机工程学系，博士

2009.09 – 2013.06，浙江大学，光电信息工程学系，本科

代表文章： 

1. Li, X.*, Wu, Y.*, Su, Y., Rey-Suarez, I.A., Matthaeus, C., Updegrove, T.B., Wei, Z., Zhang, L., Sasaki, H., Li, Y., Guo, M., Giannini, J.P., Vishwasrao, H.D., Chen, J., Lee, S-J. J., Shao, L., Liu, H., Ramamurthi, K.S., Taraska, J.W., Upadhyaya, A., La Riviere, P., Shroff, H. Three-dimensional structured illumination microscopy with enhanced axial resolution. Nature Biotechnology, 41(9), 1307-1319 (2023).

2. Li, X., Jiang, M., Lam, J. W., Tang, B. Z., & Qu, J. Y., Mitochondrial imaging with combined fluorescence and stimulated Raman scattering microscopy using a probe of the aggregation-induced emission characteristic. Journal of the American Chemical Society, 139(47), 17022-17030 (2017).

3. Li, X., Li, Y., Jiang, M., Wu, W., He, S., Chen, C., Qin, Z., Tang, B.Z., Mak, H.Y. and Qu, J.Y., Quantitative imaging of lipid synthesis and lipolysis dynamics in Caenorhabditis elegans by stimulated Raman scattering microscopy. Analytical chemistry, 91(3), 2279-2287 (2019)

4. Li, Y., Huang, S., Chan, L.S., Li, X., To, N.S., Zhao, X., Jung, K., Yang, X., Tse, Y.C., Xu, N., Xia, Y., Cheung T.H.; Qu, J.Y. and Mak, H.Y. A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis. Nature Communications, 17, 6165 (2026)

5. Chareyre, S., Li, X., Anjuwon-Foster, B.R., Updegrove, T.B., Clifford, S., Brogan, A.P., Su, Y., Zhang, L., Chen, J., Shroff, H. and Ramamurthi, K.S. Cell division machinery drives cell-specific gene activation during differentiation in Bacillus subtilis. Proceedings of the National Academy of Sciences, 121(13), e2400584121 (2024).

6. Li, Y., Su, Y., Guo, M., Han, X., Liu, J., Vishwasrao, H., Li, X., Christensen, R., Sengupta, T., Moyle, M., Chen, J., Usdin, T.B., Colón-Ramos, D., Liu, H., Wu, Y., Shroff, H. Incorporating the image formation process into deep learning improves network performance. Nature Methods, 19(11), 1427-1437 (2022).

7. Wu, W., He, S., Wu, J., Chen, C., Li, X., Liu, K. and Qu, J.Y. Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window. Nature communications, 13(1), 1959 (2022).

8. Zeng, L., Li, X., Preusch, C.B., He, G.J., Xu, N., Cheung, T.H., Qu, J. and Mak, H.Y. Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans. PLoS Genetics, 17(7), e1009635 (2021).

9. Chen, J., Sasaki, H., Lai, H., Su, Y., Liu, J., Wu, Y., Zhovmer, A., Combs, C.A., Rey-Suarez, I., Chang, H., Huang, C.C., Li, X., Guo, M., Nizambad, S., Upadhyaya, A., S-J. J. Lee, Lucas, L.A.G., Shroff, H. Three-dimensional residual channel attention networks denoise and sharpen fluorescence microscopy image volumes. Nature Methods, 18(6), 678-687 (2021).