郑问枢，博士生导师，南方科技大学助理教授，副研究员。郑问枢博士毕业于北京大学/国家纳米科学中心（2018），随后分别于亚利桑那州立大学及杜兰大学任博士后（2019-2022）、项目科学家（2022）、助理教授（2023-2026），已于2026年1月全职回国加入南方科技大学生物医学工程系。在 Nat. Biomed. Eng., Nat. Commun., Anal. Chem., ACS Nano, Nano Lett., Angew. Chem. Int. Ed., Sci. Adv., Lancet Microbe 等国际权威期刊发表论文近50篇。第一作者成果被 Nature 等专题报道，多项成果已成功转让，相关产品已进入多家国内外医院。曾获北美华人临床化学协会（NACCCA）创新奖、美国杜兰大学 Lavin-Bernick 教师奖等荣誉。任 BMEMat（IF 15.3）等期刊青年编委。

教育背景

2013年-2018年  博士，北京大学/国家纳米科学中心

2009年-2013年  本科，郑州大学

工作经历

1/2026至今 南方科技大学 生物医学工程系    助理教授

7/2019至1/2026 杜兰大学 医学院    先后任博士后、研究科学家、助理教授

9/2018-7/2019 亚利桑那州立大学 生物设计研究所 博士后

研究方向

多组学标志物筛选；单分子/单颗粒检测；高通量医学分析

代表性论文 (*通讯作者; #共同第一作者)：

1. Saliba, J., Zheng, W.* (Corresponding author), Shu, Q., Li, L., Wu, C., Xie, Y., Lyon, C., Qu, J., Huang, H., Ying, B., Hu, T.* Enhanced diagnosis of multi-drug-resistant microbes using group association modeling and machine learning. Nat. Commun. 2025, 16, 2933

2. Zheng, W., LaCourse S., Song B., Singh D., Khanna, M., Olivo J., Stern J., Escudero J., Vergara, C., Zhang, F., Li, S., Wang, S., Cranmer, L., Huang, Z., Bojanowski, C., Bao, D,, Njuguna, I., Xiao, Y., Wamalwa, D., Nguyen, D., Yang, L., Maleche-Obimbo E., Nguyen, N., Zhang, L., Phan, H., Fan, J., Ning, B., Li, C., Lyon, C., Graviss, E., John-Stewart, G., Mitchell, C., Ramsay, A., Kaushal, D., Liang, R., Pérez-Then, E., Hu, T. Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples. Nat. Biomed. Eng. 2022, 6, 979-991

3. Huang, G., Zheng, W.* (Corresponding Author), Zhou, Y., Wan, M.*, Hu, T*. Recent advances to address challenges in extracellular vesicle-based applications for lung cancer. Acta Pharm. Sin. B. 2024, 14, 3855-3875

4. Zheng, W., Hu, T. Using extracellular vesicles in blood to diagnose paediatric tuberculosis Nat. Biomed. Eng. 2022, 6, 930-931

5. Zheng, W., Saliba, J. G., Wei, X., Shu, Q., Pierson, L. M., Mao, L., Liu, C., Lyon, C. J., Li, C.-Z. Wimley, W. C., Hu, T.Y. Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum. Nano Today 2022, 45, 101515

6. Amrollahi, P., Zheng, W. (co-first author), Monk, C., Li, C., Hu, Y. Nanoplasmonic sensor approaches for sensitive detection of disease-associated exosomes, ACS Appl. Bio Mater. 2021, 4, 6589-6603 (封面)

7. Zheng, W., Jia, Y., Zhao, Y., Zhang, J., Xie, Y., Wang, L., Zhao, X., Liu, X., Tang, R., Wang, L., Jiang X. Reversing bacterial resistance to gold nanoparticles by size modulation. Nano Lett., 2021, 21, 1992-2000

8. Zheng, W., Zeng, L., Chen, Y. Bioorthogonal Reactions Amplify Magnetic Nanoparticles Binding and Assembly for Ultrasensitive Magnetic Resonance Sensing. Anal. Chem., 2020, 92, 2787-2793

9. Sun, Z., Zheng, W. (co-first author), Zhu, G., Lian, J., Wang, J., Hui, P., He, S., Chen, W., Jiang, X. Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles. ACS Appl. Mater. Interfaces, 2019, 2017, 11, 45381-45389

10. Dong, Y., Zheng, W. (co-first author), Chen, D., Li, X., Wang, J., Wang, Z., Chen, Y. Click Reaction-Mediated T2 Immunosensor for Ultrasensitive Detection of Pesticide Residues via Brush-like Nanostructure-Triggered Coordination Chemistry. J. Agric. Food Chem., 2019, 67, 9942-9949

11. Zheng, W., Li, H., Chen, W., Zhang, J., Wang, N., Guo, X., Jiang, X. Rapid detection of Cu ions in biological systems using click chemistry. Small, 2018, 14, 1703857

12. Ran, B., Zheng, W. (Co-first author), Dong, M., Xianyu, Y., Chen, Y., Wu, J., Qian, Z., Jiang, X. Peptide-mediated controllable crosslinking of gold nanoparticles for immunoassay with tunable detection range. Anal. Chem., 2018, 90, 8234–8240

13. Dong, M., Zheng, W. (Co-first author), Chen, Y., Xiangyu, Y., Ran, B., Qian, Z., Jiang, X. Fe-T1 sensor based on coordination chemistry for sensitive and versatile bioanalysis, Anal. Chem., 2018, 90, 9148–9155

14. Liu, Z., Xianyu, Y., Zheng, W. (Co-first author), Zhang, J., Chen, Y., Dong, M., Wu, J., Luo, Y., Jiang, X. T1-mediated nanosensor for immunoassay based on activatable MnO2 nano-assembly. Anal. Chem., 2018, 90, 2765−2771

15. Zheng, W., Jia, Y., Chen, W., Wang, G., Guo, X., Jiang, X. Universal coating from electrostatic self-assembly to prevent multi-drug resistant bacteria colonization on medical devices/solid surfaces. ACS Appl. Mater. Interfaces, 2017, 9, 21181-21189

16. Yin, B., Zheng, W. (Co-first author), Dong, M., Yu, W., Chen, Y., Joo, S., Jiang, X. An enzyme-mediated competitive colorimetric sensor based on Au@Ag bimetallic nanoparticles for highly sensitive detection of disease biomarkers. Analyst, 2017, 142, 2954-2960

17. Zheng, W., Li, H., Chen, W., Ji, J., Jiang, X. Recyclable colorimetric detection of trivalent cations in aqueous media using zwitterionic gold nanoparticles. Anal. Chem., 2016, 88, 4140-4146