师资

刘泉
副教授
医学院党支部书记,医学院学生工作办公室主任
0755-88018055
liuq3@sustech.edu.cn

个人简介

刘泉,医学博士,医学院副教授,副主任医师,博士生导师。1997年至2002年就读于哈尔滨医科大学,获医学学士学位。2002年至2005年就读于哈尔滨医科大学,获外科学(胸心外)硕士学位,并留校从医任教,奠定了心脏大血管外科的临床基础。2008年至2011年就读于哈尔滨医科大学,获外科学(胸心外)博士学位。2009年至2017年,在匹兹堡大学Thomas E. Starzl移植研究所先后以research fellow, postdoctoral associate 和research associate身份从事移植免疫学、炎症调控和Treg免疫生物学等方面的研究。

 

研究领域

1. 移植抗原提呈

2. 移植、炎症调控和肿瘤免疫中的IL-33、Treg和ILC2免疫生物学

3. 免疫治疗

 

教学

本科生:生物化学、生理学、病理生理学

研究生:免疫学

 

工作经历

2018.08-至今     副教授,南方科技大学医学院

2014.03-2017.04  Research Associate

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

2014.09-2018.08  副主任医师, 心血管外科,哈尔滨医科大学附属第二医院

2008.09-2014.08  主治医师, 心血管外科,哈尔滨医科大学附属第二医院

2005.07-2008.08  住院医师, 心血管外科,哈尔滨医科大学附属第二医院

 

教育背景

1997.09-2002.06    临床医学         本科    哈尔滨医科大学

2002.09-2005.06    外科学(胸心外) 硕士    哈尔滨医科大学

2008.09-2011.12    外科学(胸心外) 博士    哈尔滨医科大学

2009.02-2009.08    临床心/肺移植观摩

Presbyterian Hospital, University of Pittsburgh Medical Center, USA

2009.12-2012.03  Research fellow

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

2012.03-2014.02   博士后

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

 

已发表学术论文

1. Xiao F, Lin L, Chao Z, Shao C, Chen Z, Wei Z, Lu J, Huang Y, Li L, Liu Q, Liang Y, Tian L. Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood-Brain Barrier. Angew Chem Int Ed Engl. 2020. (影响因子257Nature Index journal

2. Lin L, Li Y, Liu M, Li Q, Liu Q#, Li R#. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging. 2020;12:1685-1703.#共同通讯作者)

3. Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6). pii: 123919.

4. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cellderived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805-20. (影响因子784,高被引论文,Nature Index journal)

5. Zhuang Q*, Liu Q*, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016;7:12623. (*共同第一作者,影响因子124Nature Index journal)

6. Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MJ, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39.(影响因子601

7. Liu Q, Turnquist HR. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant. 2016;21:45-52.

8. Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH1, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125:3183-92.(影响因子601

9. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J.Macrophage endocytosis of high-mobility group box1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39

10. Rosborough BR, Raïch-Regué D, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014;14:2173-80.

11. Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, Turnquist HR. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol. 2014;193:4010-20.

12. Rosborough BR, Mathews LR, Matta BM, Liu Q, Raïch-Regué D, Thomson AW, Turnquist HR.Cutting edge: Flt3 ligand mediates STAT3 independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol. 2014;192:3470-3.

13. Liu Q, Wang Y, Nakao A, Zhang W, Gorantla V, Zheng XX. Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats. Clin Dev Immunol. 2013; 2013:483856.

14. Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller DA. Nitric Oxide Production Upregulates Wnt/β-catenin Signaling By Inhibiting Dickkopf-1. Cancer Res. 2013; 73: 6526-37.Nature Index journal

15. Cheng L, Guo H, Qiao X, Liu Q, Nie J, Li J, Wang J, Jiang K. T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading. Diagn Pathol. 2013;8:16

16. Liu Q, Turnquist HR. Implications for Interleukin-33 in solid organ transplantation. Cytokine. 2013;62:183-94.

17. Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Stolz DB, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW. IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell dependent promotion of cardiac allograft survival. J Immunol. 2011; 187: 4598-610.

18. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010; 116: 2694-705. (影响因子601

19. 刘泉,杨木清,代贺龙.匹兹堡大学Starzl移植研究所学习期间的见闻与思考[J].实用器官移植电子杂志,2018,6(06):477-478.

20. 刘泉,齐忠权.移植免疫与器官再生的研究进展[J].实用器官移植电子杂志,2018,6(02):90-92+82.

21. 刁力为,刘大勇,叶明,刘泉,亓峰,孙振东,陈子道,姚志发,吴乃石.热休克预适应对心脏移植供心保护作用的实验研究[J].哈尔滨医科大学学报,2010,44(05):443-446.

22. 吴乃石,刁力为,刘泉,赵林,亓锋,刘大勇.托拉塞米在重症心脏联合瓣膜置换病人围手术期中的应用[J].中国新药与临床杂志,2006(10):753-755.

23. 刘泉,吴乃石,孙露,赵林林,刁力为,陈子道,杜金荣.婴儿多发性心脏横纹肌瘤一例[J].中华外科杂志,2006(06):368.

24. 刘泉,臧旺福,田海.一种新的大鼠同种主动脉瓣异位移植模型[J].中华实验外科杂志,2005(10):114-115.

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